Phosphorothioation of DNA in bacteria by dnd genes - PubMed (original) (raw)
Phosphorothioation of DNA in bacteria by dnd genes
Lianrong Wang et al. Nat Chem Biol. 2007 Nov.
Abstract
Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
Comment in
- Phosphorothioation of DNA in bacteria.
Eckstein F. Eckstein F. Nat Chem Biol. 2007 Nov;3(11):689-90. doi: 10.1038/nchembio1107-689. Nat Chem Biol. 2007. PMID: 17948013 No abstract available.
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