Argonaute proteins: key players in RNA silencing - PubMed (original) (raw)

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doi: 10.1038/nrm2321.

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• PMID: 18073770
• DOI: 10.1038/nrm2321

Review

Argonaute proteins: key players in RNA silencing

Gyorgy Hutvagner et al. Nat Rev Mol Cell Biol. 2008 Jan.

Abstract

During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

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