Argonaute proteins: key players in RNA silencing - PubMed (original) (raw)
Review
doi: 10.1038/nrm2321.
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- PMID: 18073770
- DOI: 10.1038/nrm2321
Review
Argonaute proteins: key players in RNA silencing
Gyorgy Hutvagner et al. Nat Rev Mol Cell Biol. 2008 Jan.
Abstract
During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
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