Semaphorins and their receptors in immune cell interactions - PubMed (original) (raw)

Review

doi: 10.1038/ni1553. Epub 2007 Dec 17.

Affiliations

• PMID: 18087252
• DOI: 10.1038/ni1553

Review

Semaphorins and their receptors in immune cell interactions

Kazuhiro Suzuki et al. Nat Immunol. 2008 Jan.

Abstract

Semaphorins are newcomers to the growing panoply of immunoregulatory proteins. Members of this family were originally identified as proteins that provide axonal guidance cues during neuronal development. However, accumulating evidence indicates that several semaphorins, called 'immune semaphorins', are crucial to various phases of the immune response, from initiation to terminal inflammatory processes. Extensive studies of immune semaphorins have shown not only differences but also parallels in semaphorin functions among physiologically distinct systems, providing unexpected but meaningful insights into the biological activities of this protein family. Here we review the present knowledge of the function of semaphorins and their receptors in the immune system, including the most recent advances in this field.

PubMed Disclaimer

Similar articles

• Immune semaphorins: increasing members and their diverse roles.
  Kikutani H, Suzuki K, Kumanogoh A. Kikutani H, et al. Adv Immunol. 2007;93:121-43. doi: 10.1016/S0065-2776(06)93003-X. Adv Immunol. 2007. PMID: 17383540 Review.
• Immune semaphorins: a new area of semaphorin research.
  Kumanogoh A, Kikutani H. Kumanogoh A, et al. J Cell Sci. 2003 Sep 1;116(Pt 17):3463-70. doi: 10.1242/jcs.00674. J Cell Sci. 2003. PMID: 12893810 Review.
• Semaphorins in interactions between T cells and antigen-presenting cells.
  Kikutani H, Kumanogoh A. Kikutani H, et al. Nat Rev Immunol. 2003 Feb;3(2):159-67. doi: 10.1038/nri1003. Nat Rev Immunol. 2003. PMID: 12563299 Review.
• Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.
  Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, Ishida I, Fujimura H, Sakoda S, Yoshida K, Kikutani H. Kumanogoh A, et al. Nature. 2002 Oct 10;419(6907):629-33. doi: 10.1038/nature01037. Nature. 2002. PMID: 12374982
• [Regulation of immune responses by immune semaphorins].
  Ito D, Nojima S, Kumanogoh A. Ito D, et al. Nihon Rinsho. 2012 Sep;70(9):1633-43. Nihon Rinsho. 2012. PMID: 23012815 Review. Japanese.

Cited by

• SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer.
  Zhang S, Kong F, Zheng L, Li X, Jia L, Yang L. Zhang S, et al. Int J Gen Med. 2024 Sep 14;17:4081-4099. doi: 10.2147/IJGM.S474827. eCollection 2024. Int J Gen Med. 2024. PMID: 39295856 Free PMC article.
• Critical signaling molecules in the temporomandibular joint osteoarthritis under different magnitudes of mechanical stimulation.
  Liu Y, Jia F, Li K, Liang C, Lin X, Geng W, Li Y. Liu Y, et al. Front Pharmacol. 2024 Jul 11;15:1419494. doi: 10.3389/fphar.2024.1419494. eCollection 2024. Front Pharmacol. 2024. PMID: 39055494 Free PMC article. Review.
• Asiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice.
  Zhang J, Zhao H, Wang F, Zhou J, Li M, Li H, Ren M, Wang L, Ren Q, Zhong X, Jiang X, Zhang Z. Zhang J, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7573-7587. doi: 10.1007/s00210-024-03091-x. Epub 2024 Apr 26. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38664244 Free PMC article.
• The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis.
  Rosik J, Kulpa J, Szczepanik M, Pawlik A. Rosik J, et al. Cells. 2024 Apr 2;13(7):618. doi: 10.3390/cells13070618. Cells. 2024. PMID: 38607057 Free PMC article. Review.
• FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression.
  Liu Z, Meng X, Zhang Y, Sun J, Tang X, Zhang Z, Liu L, He Y. Liu Z, et al. Int J Oral Sci. 2024 Mar 28;16(1):26. doi: 10.1038/s41368-024-00289-w. Int J Oral Sci. 2024. PMID: 38548747 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • Guide to Pharmacology