Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle - PubMed (original) (raw)

Comparative Study

. 1991 May 17;65(4):701-13.

doi: 10.1016/0092-8674(91)90101-4.

Affiliations

• PMID: 1827757
• DOI: 10.1016/0092-8674(91)90101-4

Comparative Study

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

H Matsushime et al. Cell. 1991.

Abstract

Three mouse cyclin-like (CYL) genes were isolated, two of which are regulated by colony-stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle. CSF-1 deprivation during G1 leads to rapid degradation of CYL proteins (p36CYL) and correlates with failure to initiate DNA synthesis. However, after entering S phase, macrophages no longer require CSF-1 and can complete cell division without expressing CYL genes. During G1, p36CYL is phosphorylated and associates with a polypeptide antigenically related to p34cdc2. The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment.

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