Future directions in regional treatment strategies for melanoma and sarcoma - PubMed (original) (raw)
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Future directions in regional treatment strategies for melanoma and sarcoma
G M Beasley et al. Int J Hyperthermia. 2008 May.
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Abstract
Hyperthermic isolated limb perfusion (HILP) with melphalan and more recently isolated limb infusion (ILI) with melphalan +/- dactinomycin are common treatment modalities for both in-transit melanoma of the extremity and advanced extremity sarcoma. In order to further optimize treatment, future research should focus on selection of appropriate patients, verification of a technique that produces consistent results while maintaining acceptable toxicity, and development of novel strategies and agents. Development of these novel agents and strategies has potential to not only improve the efficacy of regional chemotherapy but may also help guide future strategies for systemic treatment.
Comment in
- Isolated limb perfusion for malignant melanoma; possibly better results with high dose hyperthermia.
Van der Zee J, Kroon BB. Van der Zee J, et al. Int J Hyperthermia. 2008 Nov;24(7):602-3; author reply 604. doi: 10.1080/02656730802235536. Int J Hyperthermia. 2008. PMID: 18979311 No abstract available.
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