DNA methylation landscapes: provocative insights from epigenomics - PubMed (original) (raw)
Review
doi: 10.1038/nrg2341.
Affiliations
- PMID: 18463664
- DOI: 10.1038/nrg2341
Review
DNA methylation landscapes: provocative insights from epigenomics
Miho M Suzuki et al. Nat Rev Genet. 2008 Jun.
Abstract
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.
Similar articles
- Genomic patterns of DNA methylation: targets and function of an epigenetic mark.
Weber M, Schübeler D. Weber M, et al. Curr Opin Cell Biol. 2007 Jun;19(3):273-80. doi: 10.1016/j.ceb.2007.04.011. Epub 2007 Apr 26. Curr Opin Cell Biol. 2007. PMID: 17466503 Review. - The value-added genome: building and maintaining genomic cytosine methylation landscapes.
Rangwala SH, Richards EJ. Rangwala SH, et al. Curr Opin Genet Dev. 2004 Dec;14(6):686-91. doi: 10.1016/j.gde.2004.09.009. Curr Opin Genet Dev. 2004. PMID: 15531165 Review. - Heritable alteration in DNA methylation pattern occurred specifically at mobile elements in rice plants following hydrostatic pressurization.
Long L, Lin X, Zhai J, Kou H, Yang W, Liu B. Long L, et al. Biochem Biophys Res Commun. 2006 Feb 10;340(2):369-76. doi: 10.1016/j.bbrc.2005.12.015. Epub 2005 Dec 13. Biochem Biophys Res Commun. 2006. PMID: 16364243 - Introduction to epigenomics and epigenome-wide analysis.
Fazzari MJ, Greally JM. Fazzari MJ, et al. Methods Mol Biol. 2010;620:243-65. doi: 10.1007/978-1-60761-580-4_7. Methods Mol Biol. 2010. PMID: 20652507 Review. - Epigenomics: Tackling the epigenome.
[No authors listed] [No authors listed] Nature. 2008 Aug 7;454(7205):795. doi: 10.1038/454795b. Nature. 2008. PMID: 18685709 No abstract available.
Cited by
- Variations in genomic DNA methylation during the long-term in vitro proliferation of oil palm embryogenic suspension cultures.
Rival A, Ilbert P, Labeyrie A, Torres E, Doulbeau S, Personne A, Dussert S, Beulé T, Durand-Gasselin T, Tregear JW, Jaligot E. Rival A, et al. Plant Cell Rep. 2013 Mar;32(3):359-68. doi: 10.1007/s00299-012-1369-y. Epub 2012 Nov 23. Plant Cell Rep. 2013. PMID: 23179461 - Identification of transcriptome SNPs for assessing allele-specific gene expression in a super-hybrid rice Xieyou9308.
Zhai R, Feng Y, Zhan X, Shen X, Wu W, Yu P, Zhang Y, Chen D, Wang H, Lin Z, Cao L, Cheng S. Zhai R, et al. PLoS One. 2013 Apr 17;8(4):e60668. doi: 10.1371/journal.pone.0060668. Print 2013. PLoS One. 2013. PMID: 23613738 Free PMC article. - DNA methylation and transcriptional noise.
Huh I, Zeng J, Park T, Yi SV. Huh I, et al. Epigenetics Chromatin. 2013 Apr 26;6(1):9. doi: 10.1186/1756-8935-6-9. Epigenetics Chromatin. 2013. PMID: 23618007 Free PMC article. - Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation.
Rijnkels M, Freeman-Zadrowski C, Hernandez J, Potluri V, Wang L, Li W, Lemay DG. Rijnkels M, et al. PLoS One. 2013;8(1):e53270. doi: 10.1371/journal.pone.0053270. Epub 2013 Jan 2. PLoS One. 2013. PMID: 23301053 Free PMC article. - Emerging Role of RNA m5C Modification in Cardiovascular Diseases.
Balachander K, Priyadharsini JV, Roy A, Paramasivam A. Balachander K, et al. J Cardiovasc Transl Res. 2023 Jun;16(3):598-605. doi: 10.1007/s12265-022-10336-8. Epub 2022 Nov 1. J Cardiovasc Transl Res. 2023. PMID: 36318418 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources