Arginine methylation of hnRNP K enhances p53 transcriptional activity - PubMed (original) (raw)
. 2008 May 28;582(12):1761-5.
doi: 10.1016/j.febslet.2008.04.051. Epub 2008 May 8.
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- PMID: 18472002
- DOI: 10.1016/j.febslet.2008.04.051
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Arginine methylation of hnRNP K enhances p53 transcriptional activity
Yibin Chen et al. FEBS Lett. 2008.
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Abstract
Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.
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