Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure - PubMed (original) (raw)
Comparative Study
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
Cathrine Husberg et al. J Mol Cell Cardiol. 2008 Aug.
Abstract
Several lines of evidence suggest that inflammatory processes mediated by cytokines are involved in the pathogenesis of heart failure (HF). However, the regulation of cytokine expression and the role of cytokines during HF development are not well understood. To address this issue, we have examined alterations in gene expression during HF progression by microarray technology in non-infarcted left ventricular (LV) murine tissue at various time points after myocardial infarction (MI). The highest number of regulated genes was found five days after MI. In total, we identified 14 regulated genes encoding cytokines with no previous association to HF. The strongest up-regulation was found for the chemokine fractalkine (CX3CL1). In human failing hearts we detected a 3-fold increase in CX3CL1 protein production, and both cardiomyocytes and fibrous tissue revealed immunoreactivity for CX3CL1 and its specific receptor CX3CR1. We also found that the circulating level of CX3CL1 was increased in patients with chronic HF in accordance with disease severity (1.6-fold in NYHA II, 2.2-fold in NYHA III and 2.9-fold in NYHA IV). In vitro experiments demonstrated that CX3CL1 production could be induced by inflammatory cytokines known to be highly expressed in HF. CX3CL1 itself induced the expression of markers of cardiac hypertrophy and protein phosphatases in neonatal cardiomyocytes. Given the increased CX3CL1 production in both an experimental HF model and in patients with chronic HF as well as its direct effects on cardiomyocytes, we suggest a role for CX3CL1 and its receptor CX3CR1 in the pathogenesis of HF.
Similar articles
- Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.
Dahl CP, Husberg C, Gullestad L, Waehre A, Damås JK, Vinge LE, Finsen AV, Ueland T, Florholmen G, Aakhus S, Halvorsen B, Aukrust P, Oie E, Yndestad A, Christensen G. Dahl CP, et al. Circ Heart Fail. 2009 Nov;2(6):624-32. doi: 10.1161/CIRCHEARTFAILURE.108.821074. Epub 2009 Sep 22. Circ Heart Fail. 2009. PMID: 19919988 - Elevated levels of activin A in heart failure: potential role in myocardial remodeling.
Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland SS, Gullestad L, Christensen G, Damås JK, Aukrust P. Yndestad A, et al. Circulation. 2004 Mar 23;109(11):1379-85. doi: 10.1161/01.CIR.0000120704.97934.41. Epub 2004 Mar 1. Circulation. 2004. PMID: 14993131 - Detrimental effect of fractalkine on myocardial ischaemia and heart failure.
Xuan W, Liao Y, Chen B, Huang Q, Xu D, Liu Y, Bin J, Kitakaze M. Xuan W, et al. Cardiovasc Res. 2011 Dec 1;92(3):385-93. doi: 10.1093/cvr/cvr221. Epub 2011 Aug 12. Cardiovasc Res. 2011. PMID: 21840883 - Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer.
Marchesi F, Locatelli M, Solinas G, Erreni M, Allavena P, Mantovani A. Marchesi F, et al. J Neuroimmunol. 2010 Jul 27;224(1-2):39-44. doi: 10.1016/j.jneuroim.2010.05.007. Epub 2010 Jul 13. J Neuroimmunol. 2010. PMID: 20630606 Review. - Animal models for heart failure.
Gupta S, Sen S. Gupta S, et al. Methods Mol Med. 2006;129:97-114. doi: 10.1385/1-59745-213-0:97. Methods Mol Med. 2006. PMID: 17085807 Review.
Cited by
- Parenchymal and Stromal Cells Contribute to Pro-Inflammatory Myocardial Environment at Early Stages of Diabetes: Protective Role of Resveratrol.
Savi M, Bocchi L, Sala R, Frati C, Lagrasta C, Madeddu D, Falco A, Pollino S, Bresciani L, Miragoli M, Zaniboni M, Quaini F, Del Rio D, Stilli D. Savi M, et al. Nutrients. 2016 Nov 16;8(11):729. doi: 10.3390/nu8110729. Nutrients. 2016. PMID: 27854328 Free PMC article. - The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Restores Cardiomyocyte Contractility in a Rat Model of Early Diabetes.
Bocchi L, Motta BM, Savi M, Vilella R, Meraviglia V, Rizzi F, Galati S, Buschini A, Lazzaretti M, Pramstaller PP, Rossini A, Stilli D. Bocchi L, et al. Int J Mol Sci. 2019 Apr 16;20(8):1873. doi: 10.3390/ijms20081873. Int J Mol Sci. 2019. PMID: 31014028 Free PMC article. - Recent Advances in GPCR-Regulated Leukocyte Responses during Acute Cardiac Injury.
Nayak TK, Tilley DG. Nayak TK, et al. Curr Opin Physiol. 2021 Feb;19:55-61. doi: 10.1016/j.cophys.2020.09.007. Epub 2020 Sep 15. Curr Opin Physiol. 2021. PMID: 33244505 Free PMC article. - Targeting the chemokines in cardiac repair.
Cavalera M, Frangogiannis NG. Cavalera M, et al. Curr Pharm Des. 2014;20(12):1971-9. doi: 10.2174/13816128113199990449. Curr Pharm Des. 2014. PMID: 23844733 Free PMC article. Review. - Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation.
Pechenino AS, Lin L, Mbai FN, Lee AR, He XM, Stallone JN, Knowlton AA. Pechenino AS, et al. Physiol Genomics. 2011 Sep 22;43(18):1065-73. doi: 10.1152/physiolgenomics.00228.2010. Epub 2011 Jul 12. Physiol Genomics. 2011. PMID: 21750230 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous