Expression of Indian Hedgehog signaling molecules in breast cancer - PubMed (original) (raw)

. 2009 Feb;135(2):235-40.

doi: 10.1007/s00432-008-0451-x. Epub 2008 Jul 18.

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Expression of Indian Hedgehog signaling molecules in breast cancer

Yanhua Xuan et al. J Cancer Res Clin Oncol. 2009 Feb.

Abstract

Purpose: To investigate the clinicopathological significance and expression pattern of Hedgehog (Hh) signaling molecules in breast normal glands and invasive ductal carcinoma.

Materials and methods: A total of 142 cases, including 21 of normal breast and 121 of invasive ductal carcinoma of the breast, were immunohistochemically analyzed for Ihh, Ptch, Smo, Gli-1, Gli-2, and Gli-3 protein expression.

Results: All of Hh signaling molecules were greatly enhanced in invasive ductal carcinoma compared with the normal breast epithelia. The expressions of Ihh, Smo, and Gli-2 were increased in PR negative cases, and the expressions of Ihh, Ptch, and Gli-1/2/3 were statistically correlated with increased proliferating index of Ki-67 in invasive ductal carcinoma. Ihh and Gli-1/2/3 expressions were correlated with node metastasis. Additionally, the protein expressions of Ihh, Ptch, and Gli-2 were correlated with the clinical stage of breast cancer.

Conclusions: Hedgehog signaling molecules play an important role in the progression of invasive ductal carcinoma of breast.

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