Genetic interactions at the FLA10 locus: suppressors and synthetic phenotypes that affect the cell cycle and flagellar function in Chlamydomonas reinhardtii - PubMed (original) (raw)

Genetic interactions at the FLA10 locus: suppressors and synthetic phenotypes that affect the cell cycle and flagellar function in Chlamydomonas reinhardtii

F G Lux 3rd et al. Genetics. 1991 Jul.

Abstract

Through the isolation of suppressors of temperature-sensitive flagellar assembly mutations at the FLA10 locus of Chlamydomonas reinhardtii, we have identified six other genes involved in flagellar assembly. Mutations at these suppressor loci, termed SUF1-SUF6, display allele specificity with respect to which fla10- mutant alleles they suppress. An additional mutation, apm1-122, which confers resistance to the plant herbicides amiprophos-methyl and oryzalin, was also found to interact with mutations at the FLA10 locus. The apm1-122 mutation in combination with three fla10- mutant alleles results in synthetic cold-sensitive cell division defects, and in combination with an additional pseudo-wild-type fla10- allele yields a synthetic temperature-sensitive flagellar motility phenotype. Based upon the genetic interactions of these loci, we propose that the FLA10 gene product interacts with multiple components of the flagellar apparatus and plays a role both in flagellar assembly and in the cell cycle.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Plant Physiol. 1978 Apr;61(4):549-55 - PubMed
    1. Genetics. 1982 Apr;100(4):579-86 - PubMed
    1. Nature. 1950 Jun 3;165(4205):893 - PubMed
    1. Annu Rev Microbiol. 1960;14:197-216 - PubMed
    1. Ann N Y Acad Sci. 1953 Oct 14;56(5):831-8 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources