Cancer stem cells in solid tumours: accumulating evidence and unresolved questions - PubMed (original) (raw)
Review
doi: 10.1038/nrc2499. Epub 2008 Sep 11.
Affiliations
- PMID: 18784658
- DOI: 10.1038/nrc2499
Review
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E Visvader et al. Nat Rev Cancer. 2008 Oct.
Abstract
Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.
Comment in
- On the abundance of EpCAM on cancer stem cells.
Gires O, Klein CA, Baeuerle PA. Gires O, et al. Nat Rev Cancer. 2009 Feb;9(2):143; author reply 143. doi: 10.1038/nrc2499-c1. Epub 2009 Jan 9. Nat Rev Cancer. 2009. PMID: 19132011 No abstract available.
Similar articles
- Insights into the cell of origin in breast cancer and breast cancer stem cells.
Lindeman GJ, Visvader JE. Lindeman GJ, et al. Asia Pac J Clin Oncol. 2010 Jun;6(2):89-97. doi: 10.1111/j.1743-7563.2010.01279.x. Asia Pac J Clin Oncol. 2010. PMID: 20565420 Review. - Pancreatic cancer stem cells--insights and perspectives.
Hermann PC, Mueller MT, Heeschen C. Hermann PC, et al. Expert Opin Biol Ther. 2009 Oct;9(10):1271-8. doi: 10.1517/14712590903246362. Expert Opin Biol Ther. 2009. PMID: 19723015 Review. - Therapeutic approaches targeting cancer stem cells.
Pan Y, Ma S, Cao K, Zhou S, Zhao A, Li M, Qian F, Zhu C. Pan Y, et al. J Cancer Res Ther. 2018;14(7):1469-1475. doi: 10.4103/jcrt.JCRT_976_17. J Cancer Res Ther. 2018. PMID: 30589025 Review. - Cancer stem cells and metastasis.
Sampieri K, Fodde R. Sampieri K, et al. Semin Cancer Biol. 2012 Jun;22(3):187-93. doi: 10.1016/j.semcancer.2012.03.002. Semin Cancer Biol. 2012. PMID: 22774232 Review. - Cancer Stem Cells: Root of the Evil.
Erkisa M, Karakas D, Ulukaya E. Erkisa M, et al. Crit Rev Oncog. 2019;24(1):69-87. doi: 10.1615/CritRevOncog.2019029512. Crit Rev Oncog. 2019. PMID: 31679222 Review.
Cited by
- Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment.
Nguyen MH, Nguyen TYN, Le THN, Le TNT, Chau NTN, Le TMH, Huy Nguyen BQ. Nguyen MH, et al. Heliyon. 2024 Oct 11;10(20):e39229. doi: 10.1016/j.heliyon.2024.e39229. eCollection 2024 Oct 30. Heliyon. 2024. PMID: 39492898 Free PMC article. Review. - Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.
Visco ZR, Sfakianos G, Grenier C, Boudreau MH, Simpson S, Rodriguez I, Whitaker R, Yao DY, Berchuck A, Murphy SK, Huang Z. Visco ZR, et al. Front Oncol. 2021 Mar 22;11:620873. doi: 10.3389/fonc.2021.620873. eCollection 2021. Front Oncol. 2021. PMID: 33828978 Free PMC article. - Peripheral blood mononuclear CD133 mRNA levels correlates with response to treatment in patients with gastrointestinal stromal tumors.
Deng Y, Hassan MM, Mo J, Lin EH. Deng Y, et al. PLoS One. 2013;8(2):e55520. doi: 10.1371/journal.pone.0055520. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23408993 Free PMC article. - Regulation of NANOG in cancer cells.
Gong S, Li Q, Jeter CR, Fan Q, Tang DG, Liu B. Gong S, et al. Mol Carcinog. 2015 Sep;54(9):679-87. doi: 10.1002/mc.22340. Epub 2015 May 27. Mol Carcinog. 2015. PMID: 26013997 Free PMC article. Review. - MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application.
Aslam MI, Patel M, Singh B, Jameson JS, Pringle JH. Aslam MI, et al. J Transl Med. 2012 Jun 20;10:128. doi: 10.1186/1479-5876-10-128. J Transl Med. 2012. PMID: 22716183 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases