Derailed endocytosis: an emerging feature of cancer - PubMed (original) (raw)
Review
doi: 10.1038/nrc2521.
Affiliations
- PMID: 18948996
- DOI: 10.1038/nrc2521
Review
Derailed endocytosis: an emerging feature of cancer
Yaron Mosesson et al. Nat Rev Cancer. 2008 Nov.
Abstract
Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past 5 years as a multifaceted hallmark of malignant cells. In line with the cooperative nature of endocytic machineries, multiple oncogenic alterations underlie defective endocytosis, such as altered ubiquitylation (Cbl and Nedd4 ubiquitin ligases, for example), altered cytoskeletal interactions and alterations to Rab family members. Pharmaceutical interception of the propensity of tumour cells to derail their signalling and their adhesion receptors may constitute a novel target for cancer therapy.
Comment in
- Mechanism of E-cadherin lysosomal degradation.
Wu WJ, Hirsch DS. Wu WJ, et al. Nat Rev Cancer. 2009 Feb;9(2):143; author reply 143. doi: 10.1038/nrc2521-c1. Epub 2009 Jan 16. Nat Rev Cancer. 2009. PMID: 19148182 No abstract available.
Similar articles
- Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases.
Rotin D, Staub O, Haguenauer-Tsapis R. Rotin D, et al. J Membr Biol. 2000 Jul 1;176(1):1-17. doi: 10.1007/s00232001079. J Membr Biol. 2000. PMID: 10882424 Review. - Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.
Marmor MD, Yarden Y. Marmor MD, et al. Oncogene. 2004 Mar 15;23(11):2057-70. doi: 10.1038/sj.onc.1207390. Oncogene. 2004. PMID: 15021893 Review. - The role of ubiquitylation in signaling by growth factors: implications to cancer.
Shtiegman K, Yarden Y. Shtiegman K, et al. Semin Cancer Biol. 2003 Feb;13(1):29-40. doi: 10.1016/s1044-579x(02)00097-4. Semin Cancer Biol. 2003. PMID: 12507554 Review. - Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.
Sehat B, Andersson S, Girnita L, Larsson O. Sehat B, et al. Cancer Res. 2008 Jul 15;68(14):5669-77. doi: 10.1158/0008-5472.CAN-07-6364. Cancer Res. 2008. PMID: 18632619 - Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.
Stang E, Blystad FD, Kazazic M, Bertelsen V, Brodahl T, Raiborg C, Stenmark H, Madshus IH. Stang E, et al. Mol Biol Cell. 2004 Aug;15(8):3591-604. doi: 10.1091/mbc.e04-01-0041. Epub 2004 Jun 11. Mol Biol Cell. 2004. PMID: 15194809 Free PMC article.
Cited by
- VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination.
Wang J, Liu P, Zhang R, Xing B, Chen G, Han L, Yu J. Wang J, et al. Cell Death Dis. 2024 Oct 23;15(10):772. doi: 10.1038/s41419-024-07155-x. Cell Death Dis. 2024. PMID: 39443476 Free PMC article. - Odin (ANKS1A) modulates EGF receptor recycling and stability.
Tong J, Sydorskyy Y, St-Germain JR, Taylor P, Tsao MS, Moran MF. Tong J, et al. PLoS One. 2013 Jun 25;8(6):e64817. doi: 10.1371/journal.pone.0064817. Print 2013. PLoS One. 2013. PMID: 23825523 Free PMC article. - Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate.
Duncan R, Sat-Klopsch YN, Burger AM, Bibby MC, Fiebig HH, Sausville EA. Duncan R, et al. Cancer Chemother Pharmacol. 2013 Aug;72(2):417-27. doi: 10.1007/s00280-013-2209-7. Cancer Chemother Pharmacol. 2013. PMID: 23797686 Free PMC article. - Efficient blockade of Akt signaling is a determinant factor to overcome resistance to matuzumab.
Meira DD, Almeida VH, Mororó JS, Caetano MS, Nóbrega IP, Batista D, Sternberg C, Ferreira CG. Meira DD, et al. Mol Cancer. 2011 Dec 20;10:151. doi: 10.1186/1476-4598-10-151. Mol Cancer. 2011. PMID: 22185378 Free PMC article. - Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A-Mediated Endolysosomal Trafficking and Degradation of EGFR.
Cao P, Chen H, Zhang Y, Zhang Q, Shi M, Han H, Wang X, Jin L, Guo B, Hao R, Zhao X, Li Y, Gao C, Liu X, Wang Y, Yang A, Yang C, Si A, Li H, Song Q, He F, Zhou G. Cao P, et al. Adv Sci (Weinh). 2024 Oct;11(40):e2405459. doi: 10.1002/advs.202405459. Epub 2024 Aug 29. Adv Sci (Weinh). 2024. PMID: 39206796 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous