ERGR: An ethanol-related gene resource - PubMed (original) (raw)

. 2009 Jan;37(Database issue):D840-5.

doi: 10.1093/nar/gkn816. Epub 2008 Oct 31.

Affiliations

An-Yuan Guo et al. Nucleic Acids Res. 2009 Jan.

Abstract

Over the last decade rapid progress has been made in the study of ethanol-related traits including alcohol abuse and dependence, and behavioral responses to ethanol in both humans and animal models. To collect, curate, integrate these results so as to make them easily accessible and interpretable for researchers, we developed ERGR, a comprehensive ethanol-related gene resource. We collected and curated more than 30 large-scale data sets including linkage, association and microarray gene expression from the literature and 21 mouse QTLs from public databases. At present, the ERGR deposits ethanol-related information of approximately 7000 genes from five organisms: human (3311), mouse (2129), rat (679), fly (614) and worm (228). ERGR provides gene annotations and orthologs, detailed gene study information (e.g. fold changes of gene expression, P-values), and both the text and BLAST searches. Moreover, ERGR has data integration tools such as for data union and intersection, and candidate gene selection based on evidence in multiple datasets or organisms. The ERGR database is evolving with new data releases. More functions will also be added. ERGR has a user-friendly web interface with browse and search functions at multiple levels. It is freely available at http://bioinfo.vipbg.vcu.edu/ERGR/.

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Figures

Figure 1.

Figure 1.

An example of data integration and gene information page. (A) Functional menu on the head of each page. (B) Data browser by method or dataset. (C) Data integration page. (D) An example of data integration. (E) Detailed information of each gene identified by the data integration (partial page).

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