A dynamic view of the spread and intracellular distribution of Salmonella enterica - PubMed (original) (raw)
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A dynamic view of the spread and intracellular distribution of Salmonella enterica
Pietro Mastroeni et al. Nat Rev Microbiol. 2009 Jan.
Abstract
The events that determine the dynamics of proliferation, spread and distribution of microbial pathogens within their hosts are surprisingly heterogeneous and poorly understood. We contend that understanding these phenomena at a sophisticated level with the help of mathematical models is a prerequisite for the development of truly novel, targeted preventative measures and drug regimes. We describe here recent studies of Salmonella enterica infections in mice which suggest that bacteria resist the antimicrobial environment inside host cells and spread to new sites, where infection foci develop, and thus avoid local escalation of the adaptive immune response. We further describe implications for our understanding of the pathogenic mechanism inside the host.
References
- Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189-93 - PubMed
- Immunology. 1979 Jun;37(2):329-32 - PubMed
- Pediatr Infect Dis J. 2006 Aug;25(8):700-5 - PubMed
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):310-4 - PubMed
- Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13997-4001 - PubMed
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