Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis - PubMed (original) (raw)
. 2009 Oct;19(10):928-36.
doi: 10.1002/hipo.20545.
Affiliations
- PMID: 19212941
- DOI: 10.1002/hipo.20545
Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
Karin Van der Borght et al. Hippocampus. 2009 Oct.
Abstract
Increased levels of angiogenesis and neurogenesis possibly mediate the beneficial effects of physical activity on hippocampal plasticity. This study was designed to investigate the temporal dynamics of exercise-induced changes in hippocampal angiogenesis and cell proliferation. Mice were housed with a running wheel for 1, 3, or 10 days. Analysis of glucose transporter Glut1-positive vessel density showed a significant increase after 3 days of wheel running. Cell proliferation in the dentate gyrus showed a trend towards an increase after 3 days of running and was significantly elevated after 10 days of physical exercise. Ten days of wheel running resulted in a near-significant increase in the number of immature neurons, as determined by a doublecortin (DCX) staining. In the second part of the study, the persistence of the exercise-induced changes in angiogenesis and cell proliferation was determined. The running wheel was removed from the cage after 10 days of physical activity. Glut-1 positive vessel density and hippocampal cell proliferation were determined 1 and 6 days after removal of the wheel. Both parameters had returned to baseline 24 h after cessation of physical activity. The near-significant increase in the number of DCX-positive immature neurons persisted for at least 6 days, indicating that new neurons formed during the period of increased physical activity had survived. Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity.
Copyright 2008 Wiley-Liss, Inc.
Similar articles
- Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice.
Bednarczyk MR, Aumont A, Décary S, Bergeron R, Fernandes KJ. Bednarczyk MR, et al. Hippocampus. 2009 Oct;19(10):913-27. doi: 10.1002/hipo.20621. Hippocampus. 2009. PMID: 19405143 - Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis.
Fuss J, Ben Abdallah NM, Vogt MA, Touma C, Pacifici PG, Palme R, Witzemann V, Hellweg R, Gass P. Fuss J, et al. Hippocampus. 2010 Mar;20(3):364-76. doi: 10.1002/hipo.20634. Hippocampus. 2010. PMID: 19452518 - Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus.
Aberg E, Perlmann T, Olson L, Brené S. Aberg E, et al. Hippocampus. 2008;18(8):785-92. doi: 10.1002/hipo.20438. Hippocampus. 2008. PMID: 18493951 - Running in laboratory and wild rodents: differences in context sensitivity and plasticity of hippocampal neurogenesis.
Klaus F, Amrein I. Klaus F, et al. Behav Brain Res. 2012 Feb 14;227(2):363-70. doi: 10.1016/j.bbr.2011.04.027. Epub 2011 Apr 27. Behav Brain Res. 2012. PMID: 21549157 Review. - Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress.
Yau SY, Lau BW, So KF. Yau SY, et al. Cell Transplant. 2011;20(1):99-111. doi: 10.3727/096368910X532846. Epub 2010 Sep 30. Cell Transplant. 2011. PMID: 20887683 Review.
Cited by
- In-Patient Multimodal Intensive Neurorehabilitation and Care Improve Motor and Non-Motor Functions in the Moderately Advanced Stages of Parkinson's Disease: A Retrospective Study in a U.S. Facility.
Moondra P, Rubin L, McCrossin M, Persaud A, Di Rocco A, Quartarone A, Ghilardi MF. Moondra P, et al. Biomedicines. 2024 Jul 25;12(8):1658. doi: 10.3390/biomedicines12081658. Biomedicines. 2024. PMID: 39200123 Free PMC article. - Microvascular plasticity in mouse stroke model recovery: Anatomy statistics, dynamics measured by longitudinal in vivo two-photon angiography, network vectorization.
Mihelic SA, Engelmann SA, Sadr M, Jafari CZ, Zhou A, Woods AL, Williamson MR, Jones TA, Dunn AK. Mihelic SA, et al. J Cereb Blood Flow Metab. 2024 Dec;44(12):1441-1458. doi: 10.1177/0271678X241270465. Epub 2024 Aug 7. J Cereb Blood Flow Metab. 2024. PMID: 39113424 Free PMC article. - Supplementing Best Care with Specialized Rehabilitation Treatment in Parkinson's Disease: A Retrospective Study by Different Expert Centers.
Ghilardi MF, Quartarone A, Di Rocco A, Calabrò RS, Luo S, Liu H, Norcini M, Canesi M, Cian V, Zarucchi M, Ortelli P, Volpe D, Bakdounes L, Castelli D, Di Fonzo A, Franco G, Frattini E, Avanzino L, Pelosin E, Ogliastro C, Ceravolo R, Palermo G, Tommasini L, Frosini D, Parnetti L, Tambasco N, Nigro P, Simoni S, Schmidt P. Ghilardi MF, et al. J Clin Med. 2024 May 20;13(10):2999. doi: 10.3390/jcm13102999. J Clin Med. 2024. PMID: 38792540 Free PMC article. - A New, Simple and Practical Approach to Increase the Effects of Aerobic Exercise on Serum Levels of Neurotrophic Factors in Adult Males.
Bahramnejad M, Dehnou VV, Eslami R. Bahramnejad M, et al. Int J Exerc Sci. 2023 Aug 1;16(2):932-941. eCollection 2023. Int J Exerc Sci. 2023. PMID: 37650037 Free PMC article. - Editorial: The impact of physical activity on white matter during healthy aging.
Mukaetova-Ladinska EB, Liu Y, Venneri A. Mukaetova-Ladinska EB, et al. Front Aging Neurosci. 2023 Feb 20;15:1140767. doi: 10.3389/fnagi.2023.1140767. eCollection 2023. Front Aging Neurosci. 2023. PMID: 36891554 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous