Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin - PubMed (original) (raw)

Clinical Trial

. 2009 Jun;17(6):1189-95.

doi: 10.1038/oby.2009.11. Epub 2009 Feb 26.

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Clinical Trial

Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin

Terry E Jones et al. Obesity (Silver Spring). 2009 Jun.

Abstract

The objective of this study was to investigate the effect of long-term exercise training on concentrations of five hormones related to appetite and insulin resistance in overweight adolescents. In addition, we were interested in the relationships of these hormones with each other and with anthropometric and/or cardiovascular disease marker changes. Participants were >or=the 85th percentile for BMI for age and sex and participated in an 8-month supervised aerobic training program. Anthropometrics, cardiovascular fitness assessment, and fasting blood samples were taken pre- and post-training. Glucose, insulin, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, leptin, active ghrelin, total peptide YY (PYY), adiponectin, and resistin concentrations were measured. The participants increased their time to exhaustion on an incremental treadmill test and decreased both percent body fat and blood triglyceride concentrations. Total PYY concentration increased and resistin concentration decreased after long-term exercise training, which are favorable outcomes. Leptin concentrations were related to weight, percent body fat, waist circumference, and triglyceride concentrations pre- and post-training. The changes in resistin concentrations were related to the changes in triglyceride concentrations. We conclude that long-term exercise training has beneficial effects for overweight adolescents with respect to PYY and resistin, hormones related to appetite and insulin sensitivity.

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Conflict of interest statement

Disclosure

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

Relationship of changes in fasting triglyceride concentrations and changes in fasting resistin concentrations with long-term exercise training (p ≤ 0.05, 95% confidence interval (0.004, 0.065)).

Figure 2

Figure 2

Relationships between percent body fat and leptin concentrations (A) pre-training (p ≤ 0.001, 95% confidence interval (3.539, 9.820)) and (B) post-training (p ≤ 0.001, 95% confidence interval (2.661, 6.132)).

Figure 3

Figure 3

Relationships between triglyceride concentrations and leptin concentrations (A) pre-training (p ≤ 0.01, 95% confidence interval (−1.242, −0.282)) and (B) post-training (p ≤ 0.05, 95% confidence interval (−1.449, −0.073)).

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