Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes - PubMed (original) (raw)
Clinical Trial
doi: 10.3945/ajcn.2008.27336. Epub 2009 Apr 29.
Affiliations
- PMID: 19403641
- DOI: 10.3945/ajcn.2008.27336
Free article
Clinical Trial
Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes
Kim-Anne Lê et al. Am J Clin Nutr. 2009 Jun.
Free article
Abstract
Background: Both nutritional and genetic factors are involved in the pathogenesis of nonalcoholic fatty liver disease and insulin resistance.
Objective: The aim was to assess the effects of fructose, a potent stimulator of hepatic de novo lipogenesis, on intrahepatocellular lipids (IHCLs) and insulin sensitivity in healthy offspring of patients with type 2 diabetes (OffT2D)--a subgroup of individuals prone to metabolic disorders.
Design: Sixteen male OffT2D and 8 control subjects were studied in a crossover design after either a 7-d isocaloric diet or a hypercaloric high-fructose diet (3.5 g x kg FFM(-1) x d(-1), +35% energy intake). Hepatic and whole-body insulin sensitivity were assessed with a 2-step hyperinsulinemic euglycemic clamp (0.3 and 1.0 mU x kg(-1) x min(-1)), together with 6,6-[2H2]glucose. IHCLs and intramyocellular lipids (IMCLs) were measured by 1H-magnetic resonance spectroscopy.
Results: The OffT2D group had significantly (P < 0.05) higher IHCLs (+94%), total triacylglycerols (+35%), and lower whole-body insulin sensitivity (-27%) than did the control group. The high-fructose diet significantly increased IHCLs (control: +76%; OffT2D: +79%), IMCLs (control: +47%; OffT2D: +24%), VLDL-triacylglycerols (control: +51%; OffT2D: +110%), and fasting hepatic glucose output (control: +4%; OffT2D: +5%). Furthermore, the effects of fructose on VLDL-triacylglycerols were higher in the OffT2D group (group x diet interaction: P < 0.05).
Conclusions: A 7-d high-fructose diet increased ectopic lipid deposition in liver and muscle and fasting VLDL-triacylglycerols and decreased hepatic insulin sensitivity. Fructose-induced alterations in VLDL-triacylglycerols appeared to be of greater magnitude in the OffT2D group, which suggests that these individuals may be more prone to developing dyslipidemia when challenged by high fructose intakes. This trial was registered at clinicaltrials.gov as NCT00523562.
Similar articles
- A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans.
Lê KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, Boesch C, Ravussin E, Tappy L. Lê KA, et al. Am J Clin Nutr. 2006 Dec;84(6):1374-9. doi: 10.1093/ajcn/84.6.1374. Am J Clin Nutr. 2006. PMID: 17158419 Clinical Trial. - Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men.
Lecoultre V, Carrel G, Egli L, Binnert C, Boss A, MacMillan EL, Kreis R, Boesch C, Darimont C, Tappy L. Lecoultre V, et al. Am J Clin Nutr. 2014 Feb;99(2):268-75. doi: 10.3945/ajcn.113.069526. Epub 2013 Nov 20. Am J Clin Nutr. 2014. PMID: 24257718 Clinical Trial. - High protein intake reduces intrahepatocellular lipid deposition in humans.
Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M, Ith M, Vermathen P, Stefanoni N, Lê KA, Schneiter P, Krempf M, Vidal H, Boesch C, Tappy L. Bortolotti M, et al. Am J Clin Nutr. 2009 Oct;90(4):1002-10. doi: 10.3945/ajcn.2008.27296. Epub 2009 Aug 26. Am J Clin Nutr. 2009. PMID: 19710199 Clinical Trial. - Does fructose consumption contribute to non-alcoholic fatty liver disease?
Tappy L, Lê KA. Tappy L, et al. Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):554-60. doi: 10.1016/j.clinre.2012.06.005. Epub 2012 Jul 12. Clin Res Hepatol Gastroenterol. 2012. PMID: 22795319 Review. - Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: a systematic review and meta-analysis.
Evans RA, Frese M, Romero J, Cunningham JH, Mills KE. Evans RA, et al. Am J Clin Nutr. 2017 Aug;106(2):519-529. doi: 10.3945/ajcn.116.145169. Epub 2017 Jun 7. Am J Clin Nutr. 2017. PMID: 28592603 Review.
Cited by
- The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity.
Azevedo-Martins AK, Santos MP, Abayomi J, Ferreira NJR, Evangelista FS. Azevedo-Martins AK, et al. Nutrients. 2024 Mar 25;16(7):939. doi: 10.3390/nu16070939. Nutrients. 2024. PMID: 38612973 Free PMC article. Review. - Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD).
Singh S, Kumar A, Gupta S, Agrawal R. Singh S, et al. Tissue Barriers. 2024 Jul 2;12(3):2289830. doi: 10.1080/21688370.2023.2289830. Epub 2023 Dec 5. Tissue Barriers. 2024. PMID: 38050958 Review. - Associations between the Genetic Heritability of Dyslipidemia and Dietary Patterns in Korean Adults Based on Sex Differences.
Kim S, Jeon HK, Lee G, Kim Y, Yoo HY. Kim S, et al. Nutrients. 2023 Oct 16;15(20):4385. doi: 10.3390/nu15204385. Nutrients. 2023. PMID: 37892463 Free PMC article. - High maternal adiposity during pregnancy programs an imbalance in the lipidome and predisposes to diet-induced hepatosteatosis in the offspring.
Scheidl TB, Wager JL, Baker LG, Brightwell AL, Melan KM, Larion S, Sarr O, Regnault TR, Urbanski SJ, Thompson JA. Scheidl TB, et al. Biosci Rep. 2023 Oct 31;43(10):BSR20231060. doi: 10.1042/BSR20231060. Biosci Rep. 2023. PMID: 37706282 Free PMC article. - Diet-derived and diet-related endogenously produced palmitic acid: Effects on metabolic regulation and cardiovascular disease risk.
Annevelink CE, Sapp PA, Petersen KS, Shearer GC, Kris-Etherton PM. Annevelink CE, et al. J Clin Lipidol. 2023 Sep-Oct;17(5):577-586. doi: 10.1016/j.jacl.2023.07.005. Epub 2023 Jul 28. J Clin Lipidol. 2023. PMID: 37666689 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous