Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites - PubMed (original) (raw)

. 2009 Mar 15;199(6):899-903.

doi: 10.1086/597121.

Affiliations

• PMID: 19434915
• DOI: 10.1086/597121

Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites

Elyzana Dewi Putrianti et al. J Infect Dis. 2009.

Abstract

Liver-stage development of Plasmodium parasites represents a dramatic expansion phase for the malarial parasite between vector transmission and onset of the pathogenic blood-stage cycle. Here, we report that repeated causal-prophylactic primaquine treatment of liver-stage Plasmodium parasites in rodents elicits vaccine-like protective immunity against sporozoite-induced malaria. This regimen differs fundamentally from those involving radiation- or genetically attenuated parasites, in which long-lasting immune responses are dependent on persistence of metabolically active parasites. Pharmacological inhibition of liver-stage parasites in the rodent malaria model offers a potential fast track toward development of a vaccine that targets parasites in preerythrocytic stages.

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Comment in

• A genetically attenuated parasite vaccine does not require liver stage persistence to elicit sterile protective immunity against sporozoite-induced malaria in mice.
  Mikolajczak SA, Vaughan AM, Soliman JM, Kappe SH. Mikolajczak SA, et al. J Infect Dis. 2010 Apr 15;201(8):1270-1; author reply 1271-2. doi: 10.1086/651279. J Infect Dis. 2010. PMID: 20225958 No abstract available.

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