Health outcomes of gastric bypass patients compared to nonsurgical, nonintervened severely obese - PubMed (original) (raw)

doi: 10.1038/oby.2009.178. Epub 2009 Jun 4.

Robert C Pendleton, Michael B Strong, Ronette L Kolotkin, James M Walker, Sheldon E Litwin, Wael K Berjaoui, Michael J LaMonte, Tom V Cloward, Erick Avelar, Theophilus E Owan, Robert T Nuttall, Richard E Gress, Ross D Crosby, Paul N Hopkins, Eliot A Brinton, Wayne D Rosamond, Gail A Wiebke, Frank G Yanowitz, Robert J Farney, R Chad Halverson, Steven C Simper, Sherman C Smith, Steven C Hunt

Affiliations

Health outcomes of gastric bypass patients compared to nonsurgical, nonintervened severely obese

Ted D Adams et al. Obesity (Silver Spring). 2010 Jan.

Abstract

Favorable health outcomes at 2 years postbariatric surgery have been reported. With exception of the Swedish Obesity Subjects (SOS) study, these studies have been surgical case series, comparison of surgery types, or surgery patients compared to subjects enrolled in planned nonsurgical intervention. This study measured gastric bypass effectiveness when compared to two separate severely obese groups not participating in designed weight-loss intervention. Three groups of severely obese subjects (N = 1,156, BMI >or= 35 kg/m(2)) were studied: gastric bypass subjects (n = 420), subjects seeking gastric bypass but did not have surgery (n = 415), and population-based subjects not seeking surgery (n = 321). Participants were studied at baseline and 2 years. Quantitative outcome measures as well as prevalence, incidence, and resolution rates of categorical health outcome variables were determined. All quantitative variables (BMI, blood pressure, lipids, diabetes-related variables, resting metabolic rate (RMR), sleep apnea, and health-related quality of life) improved significantly in the gastric bypass group compared with each comparative group (all P < 0.0001, except for diastolic blood pressure and the short form (SF-36) health survey mental component score at P < 0.01). Diabetes, dyslipidemia, and hypertension resolved much more frequently in the gastric bypass group than in the comparative groups (all P < 0.001). In the surgical group, beneficial changes of almost all quantitative variables correlated significantly with the decrease in BMI. We conclude that Roux-en-Y gastric bypass surgery when compared to severely obese groups not enrolled in planned weight-loss intervention was highly effective for weight loss, improved health-related quality of life, and resolution of major obesity-associated complications measured at 2 years.

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Figures

Figure 1

Figure 1

Recruitment scheme for gastric bypass surgical patients and patients seeking gastric bypass but did not have gastric bypass surgery. *In a few instances, patients chose not to have gastric bypass surgery.

References

    1. Kushner RF, Noble CA. Long-term outcome of bariatric surgery: an interim analysis. Mayo Clin Proc. 2006;81:S46–S51. - PubMed
    1. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–1737. - PubMed
    1. Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142:547–559. - PubMed
    1. Sjöström L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683–2693. - PubMed
    1. O’Brien PE, Dixon JB, Laurie C, et al. Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program: a randomized trial. Ann Intern Med. 2006;144:625–633. - PubMed

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