Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions - PubMed (original) (raw)
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions
A J Robinson et al. Clin Exp Allergy. 2009 Dec.
Abstract
Background: Eosinophil accumulation in the lung is an important feature of airway inflammation in asthma. There is therefore much interest in developing novel therapies to prevent this process. Accumulating evidence suggests that statins have anti-inflammatory properties, including inhibition of leucocyte accumulation. We therefore assessed the ability of five statins to inhibit human eosinophil adhesion to recombinant human inter-cellular adhesion molecule (rhICAM)-1 under physiologically relevant flow conditions.
Methods: Purified eosinophils were pre-treated with a panel of statins before elucidation of the adhesion profiles of resting and granulocyte macrophage-colony stimulating factor (GM-CSF)-stimulated cells to rhICAM-1-coated microchannels at a flow rate of 0.5 dynes/cm(2). Images were recorded in real-time at 1 min intervals and analysed using Ducocell software.
Results: Fluvastatin and lovastatin (both 10 nm) significantly inhibited GM-CSF-stimulated eosinophil adhesion to rhICAM-1 after 2 min (34.4+/-3.0% inhibition and 37.8+/-12.6% inhibition, respectively, n=4, P<0.05) but had no significant inhibitory effect on unstimulated eosinophil adhesion. Mevastatin, simvastatin, and pravastatin (all 10 nm) had no significant effect on GM-CSF-stimulated eosinophil adhesion to rhICAM-1. A concentration range of fluvastatin and lovastatin inhibited GM-CSF stimulated eosinophil adhesion with significant (P<0.05) inhibition observed at low concentrations of 1 nm for both drugs. Mevalonate (100 nm) reversed fluvastatin-mediated but not lovastatin-mediated inhibition of eosinophil adhesion.
Conclusions: Inhibition of eosinophil adhesion to ICAM-1 by fluvastatin and lovastatin under physiological shear stress represent novel actions by these drugs that may inform the development of anti-inflammatory therapy for allergic disease.
Comment in
- Unsticking eosinophils.
Costello RW, Murphy DM. Costello RW, et al. Clin Exp Allergy. 2009 Dec;39(12):1778-9. doi: 10.1111/j.1365-2222.2009.03394.x. Clin Exp Allergy. 2009. PMID: 20085592 No abstract available.
Similar articles
- Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT(1)R antagonism.
Robinson AJ, Kashanin D, O'Dowd F, Williams V, Walsh GM. Robinson AJ, et al. J Leukoc Biol. 2008 Jun;83(6):1522-9. doi: 10.1189/jlb.1007717. Epub 2008 Mar 10. J Leukoc Biol. 2008. PMID: 18332235 - A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions.
Wu P, Mitchell S, Walsh GM. Wu P, et al. Clin Exp Allergy. 2005 Aug;35(8):1073-9. doi: 10.1111/j.1365-2222.2005.02290.x. Clin Exp Allergy. 2005. PMID: 16120090 - Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.
Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Weitz-Schmidt G, Nishibori M. Takahashi HK, et al. J Leukoc Biol. 2005 Mar;77(3):400-7. doi: 10.1189/jlb.0904510. Epub 2004 Dec 23. J Leukoc Biol. 2005. PMID: 15618295 - Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
Neuvonen PJ, Backman JT, Niemi M. Neuvonen PJ, et al. Clin Pharmacokinet. 2008;47(7):463-74. doi: 10.2165/00003088-200847070-00003. Clin Pharmacokinet. 2008. PMID: 18563955 Review. - New insights into the pharmacodynamic and pharmacokinetic properties of statins.
Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R, Bernini F. Corsini A, et al. Pharmacol Ther. 1999 Dec;84(3):413-28. doi: 10.1016/s0163-7258(99)00045-5. Pharmacol Ther. 1999. PMID: 10665838 Review.
Cited by
- Atorvastatin-Associated Eosinophilic Spongiosis: A Case Report and a Relevant Literature Review of Dermatological Manifestations.
Al-Moussally F, Thompson BM, Masarweh OM, Shah N, Gaudi S, Restrepo J. Al-Moussally F, et al. Cureus. 2024 May 25;16(5):e61071. doi: 10.7759/cureus.61071. eCollection 2024 May. Cureus. 2024. PMID: 38915973 Free PMC article. - Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells.
Paez PA, Kolawole M, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, Gewirtz DA, Martin RK, Ryan JJ. Paez PA, et al. J Pharmacol Exp Ther. 2020 Jul;374(1):104-112. doi: 10.1124/jpet.119.264234. Epub 2020 May 20. J Pharmacol Exp Ther. 2020. PMID: 32434944 Free PMC article. - Effective antigen presentation to helper T cells by human eosinophils.
Farhan RK, Vickers MA, Ghaemmaghami AM, Hall AM, Barker RN, Walsh GM. Farhan RK, et al. Immunology. 2016 Dec;149(4):413-422. doi: 10.1111/imm.12658. Epub 2016 Sep 20. Immunology. 2016. PMID: 27502559 Free PMC article. - Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis.
Malcomson B, Wilson H, Veglia E, Thillaiyampalam G, Barsden R, Donegan S, El Banna A, Elborn JS, Ennis M, Kelly C, Zhang SD, Schock BC. Malcomson B, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3725-34. doi: 10.1073/pnas.1520289113. Epub 2016 Jun 10. Proc Natl Acad Sci U S A. 2016. PMID: 27286825 Free PMC article. - Simvastatin Inhibits IL-5-Induced Chemotaxis and CCR3 Expression of HL-60-Derived and Human Primary Eosinophils.
Fu CH, Tsai WC, Lee TJ, Huang CC, Chang PH, Su Pang JH. Fu CH, et al. PLoS One. 2016 Jun 8;11(6):e0157186. doi: 10.1371/journal.pone.0157186. eCollection 2016. PLoS One. 2016. PMID: 27275740 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous