Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma - PubMed (original) (raw)
Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma
W D Zhang et al. Jpn J Cancer Res. 1990 Feb.
Abstract
By restriction fragment length polymorphism analysis, we examined loss of heterozygosity at 34 loci on 23 chromosomes in 35 surgically resected human hepatocellular carcinomas. Allele losses at the HP locus on chromosome 16q22 and at the MT2P1 locus on chromosome 4p11-q21 were detected in 57% (8/14) and 50% (8/16) of cases, respectively. Loss of heterozygosity on chromosomes 16q and 4 occurred simultaneously in 4 of 7 informative cases for both loci, and seemed to be important in the development of human hepatocellular carcinoma irrespective of the presence of hepatitis B virus infection. In contrast, the incidence of allele loss was low at the other loci, e.g., chromosome 1p, 3p, 11p, 13q or 17p, where one allele is frequently lost in other cancers.
Similar articles
- Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.
Tsuda H, Zhang WD, Shimosato Y, Yokota J, Terada M, Sugimura T, Miyamura T, Hirohashi S. Tsuda H, et al. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6791-4. doi: 10.1073/pnas.87.17.6791. Proc Natl Acad Sci U S A. 1990. PMID: 2168560 Free PMC article. - Loss of heterozygosity on chromosome 16 in hepatocellular carcinoma.
Sakai K, Nagahara H, Abe K, Obata H. Sakai K, et al. J Gastroenterol Hepatol. 1992 May-Jun;7(3):288-92. doi: 10.1111/j.1440-1746.1992.tb00982.x. J Gastroenterol Hepatol. 1992. PMID: 1351753 - Loss of somatic heterozygosity in hepatocellular carcinoma.
Walker GJ, Hayward NK, Falvey S, Cooksley WG. Walker GJ, et al. Cancer Res. 1991 Aug 15;51(16):4367-70. Cancer Res. 1991. PMID: 1678314 - [Loss of heterozygosity in hepatocellular carcinoma].
Takahashi K, Kudo J, Ishibashi H, Niho Y. Takahashi K, et al. Nihon Rinsho. 1993 Feb;51(2):370-4. Nihon Rinsho. 1993. PMID: 8096550 Review. Japanese. - Chromosomal localization of putative tumor-suppressor genes in several human cancers.
Yokota J, Sugimura T, Terada M. Yokota J, et al. Environ Health Perspect. 1991 Jun;93:121-3. doi: 10.1289/ehp.9193121. Environ Health Perspect. 1991. PMID: 1685440 Free PMC article. Review.
Cited by
- Alteration of WWOX in human cancer: a clinical view.
Baryła I, Styczeń-Binkowska E, Bednarek AK. Baryła I, et al. Exp Biol Med (Maywood). 2015 Mar;240(3):305-14. doi: 10.1177/1535370214561953. Epub 2015 Feb 13. Exp Biol Med (Maywood). 2015. PMID: 25681467 Free PMC article. Review. - Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.
Revill K, Wang T, Lachenmayer A, Kojima K, Harrington A, Li J, Hoshida Y, Llovet JM, Powers S. Revill K, et al. Gastroenterology. 2013 Dec;145(6):1424-35.e1-25. doi: 10.1053/j.gastro.2013.08.055. Epub 2013 Sep 5. Gastroenterology. 2013. PMID: 24012984 Free PMC article. - Prolonged exposure to acid and bile induces chromosome abnormalities that precede malignant transformation of benign Barrett's epithelium.
Bajpai M, Aviv H, Das KM. Bajpai M, et al. Mol Cytogenet. 2012 Nov 29;5(1):43. doi: 10.1186/1755-8166-5-43. Mol Cytogenet. 2012. PMID: 23194200 Free PMC article. - PTPN13/PTPL1: an important regulator of tumor aggressiveness.
Freiss G, Chalbos D. Freiss G, et al. Anticancer Agents Med Chem. 2011 Jan;11(1):78-88. doi: 10.2174/187152011794941262. Anticancer Agents Med Chem. 2011. PMID: 21235435 Free PMC article. Review. - Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway.
Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, Brennan M, Cameron JL, Klimstra DS. Abraham SC, et al. Am J Pathol. 2002 Mar;160(3):953-62. doi: 10.1016/s0002-9440(10)64917-6. Am J Pathol. 2002. PMID: 11891193 Free PMC article.
References
- ) Okuda , K. , Fujimoto , I. , Hanai , A. and Urano , Y.Changing incidence of hepatocellular carcinoma in Japan . Cancer Res. , 47 , 4967 – 4972 ( 1987. ). - PubMed
- ) Sakamoto , M. , Hirohashi , S. , Tsuda , H. , Ino , Y. , Shimosato , Y. , Yamasaki , S. , Makuuchi , M. , Hasegawa , H. , Terada , M. and Hosoda , Y.Increasing incidence of hepatocellular carcinoma possibly associated with non‐A, non‐B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases . Cancer Res. , 48 , 7294 – 7297 ( 1988. ). - PubMed
- ) Tiollais , P. , Pourcel , C. and Dejean , A.The hepatitis B virus . Nature , 317 , 489 – 495 ( 1985. ). - PubMed
- ) Rogler , C. E. , Su , C. Y. , Shafritz , D. A. , Summers , J. , Shows , T. B. , Henderson , A. and Kew , M.Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma . Science , 234 , 319 – 322 ( 1985. ). - PubMed
- ) Pasquinelli , C. , Garreau , F. , Bougueleret , L. , Cariani , E. , Grzeschik , K. H. , Thiers , V. , Croissant , O. , Hadchouel , M. , Tiollais , P. and Bréchot , C.Rearragement of a common cellular DNA domain on chromosome 4 in human primary liver tumors . J. Viro. , 62 , 629 – 632 ( 1988. ). - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous