Molecular and phenotypic variation of the Zw locus region in Drosophila melanogaster - PubMed (original) (raw)

Molecular and phenotypic variation of the Zw locus region in Drosophila melanogaster

N T Miyashita. Genetics. 1990 Jun.

Abstract

Restriction map polymorphism in a 13-kb region of the Zw locus in Drosophila melanogaster was investigated for 64 X chromosome lines with seven 6-cutter and ten 4-cutter restriction enzymes. A total of 203 restriction sites were scored, of which 20 were found to be polymorphic. The estimated nucleotide variation for this region for overall data (pi = 0.003 and 0.001, and theta = 0.003 and 0.002, for 4-cutter and 6-cutter studies, respectively) was smaller than that reported for most regions studied in D. melanogaster. It was found that the Slow allozyme has a larger nucleotide variation and haplotype diversity than the Fast allozyme. Results suggest the relatively recent divergence of the Fast allozyme from the Slow allozyme. Glucose 6-phosphate dehydrogenase (G6PD) activity was measured as a phenotype of the Zw locus. A significant difference in G6PD activity between allozymes was detected. The between-line effect was highly significant within the Slow allozyme, but was not significant within the Fast allozyme. Although a direct causative link could not be established, these results suggest an association between the amounts of quantitative and molecular genetic variation at the Zw locus region.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Genetics. 1987 Jan;115(1):129-40 - PubMed
    1. Genet Res. 1974 Feb;23(1):23-35 - PubMed
    1. Mol Biol Evol. 1989 Mar;6(2):123-30 - PubMed
    1. Science. 1964 Jan 10;143(3602):140-1 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Sep;80(17):5350-4 - PubMed

MeSH terms

Substances

LinkOut - more resources