p73 evolution - PubMed (original) (raw)

Comment

One billion years of p53/p63/p73 evolution

Vladimir A Belyi et al. Proc Natl Acad Sci U S A. 2009.

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The authors declare no conflict of interest.

Figures

Fig. 1.

The domain structure of the p53 family proteins. (A) The domain organization of human p53, p63, and p73 along with the p63/p73 ancestor proteins from Drosophila melanogaster and Caenorhabditis elegans. The percentage of identity of the amino acids and their position in the domain are given for both the DNA-binding domain and the oligomeric domain. (B) The structure of the oligomeric domain of p73 from ref. . The H-2 helix stabilizes this p73 tetramer and is absent from the p53 tetramer. p63 and p73 are more closely related to each other than to p53 based on the primary, secondary, tertiary, and quaternary structures of both the DNA-binding domains and the oligomerization domains.

Comment on

Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Joerger AC, Rajagopalan S, Natan E, Veprintsev DB, Robinson CV, Fersht AR. Joerger AC, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17705-10. doi: 10.1073/pnas.0905867106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815500 Free PMC article.

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One billion years of p53/p63/p73 evolution - PubMed (original) (raw)