Autophagy regulation by p53 - PubMed (original) (raw)
Review
Autophagy regulation by p53
Maria Chiara Maiuri et al. Curr Opin Cell Biol. 2010 Apr.
Abstract
Autophagy is an evolutionarily conserved catabolic pathway that is involved in numerous physiological processes and in multiple pathological conditions including cancer. Autophagy is regulated by an intricate network of signaling cascades that have not yet been entirely disentangled. Accumulating evidence indicates that p53, the best-characterized human tumor suppressor protein, can modulate autophagy in a dual fashion, depending on its subcellular localization. On the one hand, p53 functions as a nuclear transcription factor and transactivates proapoptotic, cell cycle-arresting and proautophagic genes. On the other hand, cytoplasmic p53 can operate at mitochondria to promote cell death and can repress autophagy via poorly characterized mechanisms. This review focuses on the recently discovered function of p53 as a master regulator of autophagy.
Copyright 2009 Elsevier Ltd. All rights reserved.
Similar articles
- p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction.
Moll UM, Marchenko N, Zhang XK. Moll UM, et al. Oncogene. 2006 Aug 7;25(34):4725-43. doi: 10.1038/sj.onc.1209601. Oncogene. 2006. PMID: 16892086 Review. - p53-mediated autophagic regulation: A prospective strategy for cancer therapy.
Tang J, Di J, Cao H, Bai J, Zheng J. Tang J, et al. Cancer Lett. 2015 Jul 28;363(2):101-7. doi: 10.1016/j.canlet.2015.04.014. Epub 2015 Apr 17. Cancer Lett. 2015. PMID: 25896632 Review. - Mitochondrial liaisons of p53.
Galluzzi L, Morselli E, Kepp O, Vitale I, Pinti M, Kroemer G. Galluzzi L, et al. Antioxid Redox Signal. 2011 Sep 15;15(6):1691-714. doi: 10.1089/ars.2010.3504. Epub 2011 Jan 7. Antioxid Redox Signal. 2011. PMID: 20712408 Review. - The role of autophagy in anticancer therapy: promises and uncertainties.
Tschan MP, Simon HU. Tschan MP, et al. J Intern Med. 2010 Nov;268(5):410-8. doi: 10.1111/j.1365-2796.2010.02266.x. J Intern Med. 2010. PMID: 20964733 - Transcription-independent p53 apoptosis: an alternative route to death.
Speidel D. Speidel D. Trends Cell Biol. 2010 Jan;20(1):14-24. doi: 10.1016/j.tcb.2009.10.002. Epub 2009 Oct 30. Trends Cell Biol. 2010. PMID: 19879762 Review.
Cited by
- Acute Endurance Exercise Induces Nuclear p53 Abundance in Human Skeletal Muscle.
Tachtsis B, Smiles WJ, Lane SC, Hawley JA, Camera DM. Tachtsis B, et al. Front Physiol. 2016 Apr 26;7:144. doi: 10.3389/fphys.2016.00144. eCollection 2016. Front Physiol. 2016. PMID: 27199762 Free PMC article. - Mechanisms and disease implications of sirtuin-mediated autophagic regulation.
Lee IH. Lee IH. Exp Mol Med. 2019 Sep 6;51(9):1-11. doi: 10.1038/s12276-019-0302-7. Exp Mol Med. 2019. PMID: 31492861 Free PMC article. Review. - Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells.
Liu L, Li H, Patterson AM, Plett PA, Sampson CH, Mohammad KS, Capitano ML, Singh P, Yao C, Orschell CM, Pelus LM. Liu L, et al. Stem Cell Rev Rep. 2022 Apr;18(4):1478-1494. doi: 10.1007/s12015-022-10368-2. Epub 2022 Mar 23. Stem Cell Rev Rep. 2022. PMID: 35318613 - BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Sheng Z, Ma L, Sun JE, Zhu LJ, Green MR. Sheng Z, et al. Blood. 2011 Sep 8;118(10):2840-8. doi: 10.1182/blood-2010-12-322537. Epub 2011 Jun 29. Blood. 2011. PMID: 21715304 Free PMC article. - The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?
Moulder DE, Hatoum D, Tay E, Lin Y, McGowan EM. Moulder DE, et al. Cancers (Basel). 2018 Jun 8;10(6):189. doi: 10.3390/cancers10060189. Cancers (Basel). 2018. PMID: 29890631 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous