YC-1 enhances natural killer cell differentiation from hematopoietic stem cells - PubMed (original) (raw)

doi: 10.1016/j.intimp.2010.01.009. Epub 2010 Jan 29.

Suk Hyung Lee, Yun Hee Kang, Mira Jeong, Mi Jeong Kim, Mi Sun Kim, Zheng-Hao Piao, Hyun-Woo Suh, Tae-don Kim, Pyung-Keun Myung, Suk-Ran Yoon, Inpyo Choi

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YC-1 enhances natural killer cell differentiation from hematopoietic stem cells

Sohyun Yun et al. Int Immunopharmacol. 2010 Apr.

Abstract

NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.

Copyright 2010 Elsevier B.V. All rights reserved.

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