YC-1 enhances natural killer cell differentiation from hematopoietic stem cells - PubMed (original) (raw)
doi: 10.1016/j.intimp.2010.01.009. Epub 2010 Jan 29.
Suk Hyung Lee, Yun Hee Kang, Mira Jeong, Mi Jeong Kim, Mi Sun Kim, Zheng-Hao Piao, Hyun-Woo Suh, Tae-don Kim, Pyung-Keun Myung, Suk-Ran Yoon, Inpyo Choi
Affiliations
- PMID: 20116458
- DOI: 10.1016/j.intimp.2010.01.009
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells
Sohyun Yun et al. Int Immunopharmacol. 2010 Apr.
Abstract
NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.
Copyright 2010 Elsevier B.V. All rights reserved.
Similar articles
- YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor.
Chiang WC, Teng CM, Lin SL, Chen YM, Tsai TJ, Hsieh BS. Chiang WC, et al. Eur J Pharmacol. 2005 Jul 4;517(1-2):1-10. doi: 10.1016/j.ejphar.2005.04.046. Eur J Pharmacol. 2005. PMID: 15950964 - Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.
Kim WS, Kim DO, Yoon SJ, Kim MJ, Yoon SR, Park YJ, Jung H, Kim TD, Kwon BM, Choi I. Kim WS, et al. Biochem Biophys Res Commun. 2012 Aug 24;425(2):340-7. doi: 10.1016/j.bbrc.2012.07.093. Epub 2012 Jul 26. Biochem Biophys Res Commun. 2012. PMID: 22842576 - Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.
Li Y, Zhao X, Tang H, Zhong Z, Zhang L, Xu R, Li S, Wang Y. Li Y, et al. Urol Int. 2012;88(1):95-101. doi: 10.1159/000331881. Epub 2011 Oct 25. Urol Int. 2012. PMID: 22041818 - Deficits in our understanding of natural killer cell development in mouse and human.
Schorr C, Krishnan MS, Capitano M. Schorr C, et al. Curr Opin Hematol. 2023 Jul 1;30(4):106-116. doi: 10.1097/MOH.0000000000000765. Epub 2023 Apr 18. Curr Opin Hematol. 2023. PMID: 37074304 Free PMC article. Review. - Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells.
Guimont-Desrochers F, Lesage S. Guimont-Desrochers F, et al. Front Immunol. 2013 Dec 11;4:446. doi: 10.3389/fimmu.2013.00446. Front Immunol. 2013. PMID: 24376447 Free PMC article. Review.
Cited by
- YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells.
Lee MR, Lin C, Lu CC, Kuo SC, Tsao JW, Juan YN, Chiu HY, Lee FY, Yang JS, Tsai FJ. Lee MR, et al. Biomedicine (Taipei). 2017 Jun;7(2):12. doi: 10.1051/bmdcn/2017070205. Epub 2017 Jun 14. Biomedicine (Taipei). 2017. PMID: 28612710 Free PMC article. - Integrated mRNA-microRNA profiling of human NK cell differentiation identifies MiR-583 as a negative regulator of IL2Rγ expression.
Yun S, Lee SU, Kim JM, Lee HJ, Song HY, Kim YK, Jung H, Park YJ, Yoon SR, Oh SR, Kim TD, Choi I. Yun S, et al. PLoS One. 2014 Oct 14;9(10):e108913. doi: 10.1371/journal.pone.0108913. eCollection 2014. PLoS One. 2014. PMID: 25313504 Free PMC article. - Innate immune natural killer cells and their role in HIV and SIV infection.
Bostik P, Takahashi Y, Mayne AE, Ansari AA. Bostik P, et al. HIV Ther. 2010 Jul 1;4(4):483-504. doi: 10.2217/HIV.10.28. HIV Ther. 2010. PMID: 20730028 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous