Vitamin D controls T cell antigen receptor signaling and activation of human T cells - PubMed (original) (raw)

doi: 10.1038/ni.1851. Epub 2010 Mar 7.

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Vitamin D controls T cell antigen receptor signaling and activation of human T cells

Marina Rode von Essen et al. Nat Immunol. 2010 Apr.

Abstract

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.

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    1. Nat Immunol. 2007 Mar;8(3):285-93 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20834-9 - PubMed
    1. Annu Rev Pharmacol Toxicol. 2006;46:355-79 - PubMed
    1. Scand J Immunol. 1988 Jun;27(6):685-96 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5207-12 - PubMed

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