The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions - PubMed (original) (raw)

The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions

N R Soman et al. Proc Natl Acad Sci U S A. 1991.

Abstract

The TPR-MET oncogenic rearrangement was originally observed in an in vitro transformed human osteosarcoma cell line. Recently, we detected the expression of this rearrangement at very low levels in several cell lines derived from human tumors of nonhematopoietic origin using a highly sensitive method based on polymerase chain reaction amplification of the transcript. We report here the results of analysis of TPR-MET expression in cell lines derived from human gastric tumors and 22 biopsy samples of human gastric mucosa showing cancer or precursor lesions. The rearranged RNA was expressed in all four cell lines as well as in biopsy samples from 12 of the 22 patients. Overexpression of TPR-MET RNA in superficial gastritis lesions with hyperplasia of glandular neck cells suggests the possible involvement of this oncogene at an early stage of gastric tumorigenesis. Analysis of gastric biopsy samples for RAS gene mutations showed base substitutions occurring in the codon 12 region of Ki- and Ha-RAS genes in four cases, including two precursor lesions.

PubMed Disclaimer

Similar articles

• TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines.
  Soman NR, Wogan GN, Rhim JS. Soman NR, et al. Proc Natl Acad Sci U S A. 1990 Jan;87(2):738-42. doi: 10.1073/pnas.87.2.738. Proc Natl Acad Sci U S A. 1990. PMID: 2300559 Free PMC article.
• Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma.
  Osaki M, Miyata H, Hayashi A, Gomyo Y, Tatebe S, Ito H. Osaki M, et al. Anticancer Res. 1996 Sep-Oct;16(5A):2881-4. Anticancer Res. 1996. PMID: 8917402
• Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma.
  Heideman DA, Snijders PJ, Bloemena E, Meijer CJ, Offerhaus GJ, Meuwissen SG, Gerritsen WR, Craanen ME. Heideman DA, et al. J Pathol. 2001 Aug;194(4):428-35. doi: 10.1002/path.934. J Pathol. 2001. PMID: 11523050
• Gene alterations in intestinal metaplasia and gastric cancer.
  Tahara E, Kuniyasu H, Yasui W, Yokozaki H. Tahara E, et al. Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S97-102. Eur J Gastroenterol Hepatol. 1994. PMID: 7735945 Review.
• Phenotypic and genotypic events in gastric carcinogenesis.
  Correa P, Shiao YH. Correa P, et al. Cancer Res. 1994 Apr 1;54(7 Suppl):1941s-1943s. Cancer Res. 1994. PMID: 8137316 Review.

Cited by

• Orchestrating the Selection and Packaging of Genomic RNA by Retroviruses: An Ensemble of Viral and Host Factors.
  Kaddis Maldonado RJ, Parent LJ. Kaddis Maldonado RJ, et al. Viruses. 2016 Sep 20;8(9):257. doi: 10.3390/v8090257. Viruses. 2016. PMID: 27657110 Free PMC article. Review.
• Value of c-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Population.
  Sun Y, Tian MM, Zhou LX, You WC, Li JY. Sun Y, et al. Chin J Cancer Res. 2012 Mar;24(1):18-22. doi: 10.1007/s11670-012-0018-x. Chin J Cancer Res. 2012. PMID: 23359758 Free PMC article.
• The effects of sodium chloride, miso or ethanol on development of intestinal metaplasia after X-irradiation of the rat glandular stomach.
  Watanabe H, Okamoto T, Takahashi T, Ogundigie PO, Ito A. Watanabe H, et al. Jpn J Cancer Res. 1992 Dec;83(12):1267-72. doi: 10.1111/j.1349-7006.1992.tb02757.x. Jpn J Cancer Res. 1992. PMID: 1483941 Free PMC article.
• MET-dependent solid tumours - molecular diagnosis and targeted therapy.
  Guo R, Luo J, Chang J, Rekhtman N, Arcila M, Drilon A. Guo R, et al. Nat Rev Clin Oncol. 2020 Sep;17(9):569-587. doi: 10.1038/s41571-020-0377-z. Epub 2020 Jun 8. Nat Rev Clin Oncol. 2020. PMID: 32514147 Free PMC article. Review.
• Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
  Weidner KM, Sachs M, Riethmacher D, Birchmeier W. Weidner KM, et al. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2597-601. doi: 10.1073/pnas.92.7.2597. Proc Natl Acad Sci U S A. 1995. PMID: 7708691 Free PMC article.

References

1. 1. J Cancer Res Clin Oncol. 1979 Jun 8;94(2):201-6 - PubMed
2. 1. Oncogene. 1990 Oct;5(10):1565-71 - PubMed
3. 1. Gan. 1983 Oct;74(5):679-86 - PubMed
4. 1. Nature. 1983 Nov 17-23;306(5940):239-42 - PubMed
5. 1. Cancer Res. 1984 Jan;44(1):1-10 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal