The centrosome and mitotic spindle apparatus in cancer and senescence - PubMed (original) (raw)

. 2010 Nov 15;9(22):4469-73.

doi: 10.4161/cc.9.22.13684.

Frank Essmann, Ion C Cirstea, Fabian Kuck, Harish C Thakur, Madhurendra Singh, Anja Kletke, Reiner U Jänicke, Constanze Wiek, Helmut Hanenberg, M Reza Ahmadian, Klaus Schulze-Osthoff, Bernd Nürnberg, Roland P Piekorz

Affiliations

• PMID: 21088502
• DOI: 10.4161/cc.9.22.13684

The centrosome and mitotic spindle apparatus in cancer and senescence

Stephen Schmidt et al. Cell Cycle. 2010.

Abstract

Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular senescence. We have complied recent evidence that inhibition or depletion of various mitotic proteins which take over key in centrosome and kinetochore integrity and mitotic checkpoint function in sufficient to activate a p53-p21(WAF) driven premature senescence phenotype. These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging.

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