The acquisition of antigen cross-presentation function by newly formed dendritic cells - PubMed (original) (raw)
. 2011 May 1;186(9):5184-92.
doi: 10.4049/jimmunol.1002683. Epub 2011 Mar 21.
Affiliations
- PMID: 21422244
- DOI: 10.4049/jimmunol.1002683
The acquisition of antigen cross-presentation function by newly formed dendritic cells
Priyanka Sathe et al. J Immunol. 2011.
Abstract
The development of Ag-presenting functions by murine dendritic cells (DCs) of the CD8(+) DC lineage was studied using a Flt-3 ligand stimulated bone-marrow culture system. Although newly formed DCs of this lineage are capable of Ag uptake and efficient presentation to T cells on MHC class II, they initially lack the ability to cross-present exogenous Ags on MHC class I. Cross-presentation capacity is acquired as a subsequent maturation step, promoted by cytokines such as GM-CSF. The development of cross-presentation capacity by the DCs in these cultures may be monitored by the parallel development of DC surface expression of CD103. However, the expression of CD103 and cross-presentation capacity are not always linked; therefore, CD103 is not an essential part of the cross-presentation machinery. These results explain the considerable variability in CD103 expression by CD8(+) DCs as well as the findings that not all DCs of this lineage are capable of cross-presentation.
Similar articles
- Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.
Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, Macary PA, Kemeny DM. Ho AW, et al. J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31. J Immunol. 2011. PMID: 22043017 - CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo.
Schliehe C, Redaelli C, Engelhardt S, Fehlings M, Mueller M, van Rooijen N, Thiry M, Hildner K, Weller H, Groettrup M. Schliehe C, et al. J Immunol. 2011 Sep 1;187(5):2112-21. doi: 10.4049/jimmunol.1002084. Epub 2011 Jul 27. J Immunol. 2011. PMID: 21795597 - GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cells.
Zhan Y, Carrington EM, van Nieuwenhuijze A, Bedoui S, Seah S, Xu Y, Wang N, Mintern JD, Villadangos JA, Wicks IP, Lew AM. Zhan Y, et al. Eur J Immunol. 2011 Sep;41(9):2585-95. doi: 10.1002/eji.201141540. Epub 2011 Aug 4. Eur J Immunol. 2011. PMID: 21660938 - Development and functional specialization of CD103+ dendritic cells.
del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Förster R. del Rio ML, et al. Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x. Immunol Rev. 2010. PMID: 20193025 Review. - The CD8+ dendritic cell subset.
Shortman K, Heath WR. Shortman K, et al. Immunol Rev. 2010 Mar;234(1):18-31. doi: 10.1111/j.0105-2896.2009.00870.x. Immunol Rev. 2010. PMID: 20193009 Review.
Cited by
- A novel in vitro model of the small intestinal epithelium in co-culture with 'gut-like' dendritic cells.
Johnston LJ, Barningham L, Campbell EL, Cerovic V, Duckworth CA, Luu L, Wastling J, Derricott H, Coombes JL. Johnston LJ, et al. Discov Immunol. 2023 Oct 7;2(1):kyad018. doi: 10.1093/discim/kyad018. eCollection 2023. Discov Immunol. 2023. PMID: 38567056 Free PMC article. - Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand.
In H, Park JS, Shin HS, Ryu SH, Sohn M, Choi W, Park S, Hwang S, Park J, Che L, Kim TG, Chu MK, Na HY, Park CG. In H, et al. Front Immunol. 2023 Nov 29;14:1179981. doi: 10.3389/fimmu.2023.1179981. eCollection 2023. Front Immunol. 2023. PMID: 38094300 Free PMC article. - Allergen-induced CD11c + dendritic cell pyroptosis aggravates allergic rhinitis.
Qiao YL, Zhu MW, Xu S, Jiao WE, Ni HF, Tao ZZ, Chen SM. Qiao YL, et al. Cell Commun Signal. 2023 Oct 10;21(1):281. doi: 10.1186/s12964-023-01309-8. Cell Commun Signal. 2023. PMID: 37817225 Free PMC article. - In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.
Gerber-Ferder Y, Bourdely P, Vetillard M, Guermonprez P, Helft J. Gerber-Ferder Y, et al. Methods Mol Biol. 2023;2618:83-92. doi: 10.1007/978-1-0716-2938-3_6. Methods Mol Biol. 2023. PMID: 36905510 - GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2.
Lellahi SM, Azeem W, Hua Y, Gabriel B, Paulsen Rye K, Reikvam H, Kalland KH. Lellahi SM, et al. Front Immunol. 2023 Jan 12;13:1058963. doi: 10.3389/fimmu.2022.1058963. eCollection 2022. Front Immunol. 2023. PMID: 36713392 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous