Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension - PubMed (original) (raw)

doi: 10.1038/nm.2337. Epub 2011 Apr 17.

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Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension

ShengYu Mu et al. Nat Med. 2011 May.

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Abstract

How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-adrenergic receptor (β(2)AR) stimulation led to decreased transcription of the gene encoding WNK4, a regulator of sodium reabsorption. β(2)AR stimulation resulted in cyclic AMP-dependent inhibition of histone deacetylase-8 (HDAC8) activity and increased histone acetylation, leading to binding of the glucocorticoid receptor to a negative glucocorticoid-responsive element in the promoter region. In rat models of salt-sensitive hypertension and sympathetic overactivity, salt loading suppressed renal WNK4 expression, activated the Na(+)-Cl(-) cotransporter and induced salt-dependent hypertension. These findings implicate the epigenetic modulation of WNK4 transcription in the development of salt-sensitive hypertension. The renal β(2)AR-WNK4 pathway may be a therapeutic target for salt-sensitive hypertension.

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References

    1. J Clin Invest. 1988 Sep;82(3):993-7 - PubMed
    1. Circ Res. 1986 Feb;58(2):241-8 - PubMed
    1. Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H1881-9 - PubMed
    1. Science. 2009 Sep 4;325(5945):1254-7 - PubMed
    1. Science. 2010 May 7;328(5979):753-6 - PubMed

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