Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program - PubMed (original) (raw)
doi: 10.1186/1550-2783-8-8.
Colin Wilborn # 2, Christopher Rasmussen # 3, Maria Ferreira # 4, Lori Greenwood # 3, Bill Campbell # 5, Chad M Kerksick # 6, Erica Nassar # 7, Rui Li # 8, Mike Iosia # 9, Matt Cooke # 10, Kristin Dugan # 2, Darryn Willoughby # 1, LuAnn Soliah # 11, Richard B Kreider # 3
Affiliations
- PMID: 21689421
- PMCID: PMC3141631
- DOI: 10.1186/1550-2783-8-8
Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program
Teresa Magrans-Courtney et al. J Int Soc Sports Nutr. 2011.
Abstract
Background: The purpose of this study was to determine whether sedentary obese women with knee OA initiating an exercise and weight loss program may experience more beneficial changes in body composition, functional capacity, and/or markers of health following a higher protein diet compared to a higher carbohydrate diet with or without GCM supplementation.
Methods: Thirty sedentary women (54 ± 9 yrs, 163 ± 6 cm, 88.6 ± 13 kg, 46.1 ± 3% fat, 33.3 ± 5 kg/m2) with clinically diagnosed knee OA participated in a 14-week exercise and weight loss program. Participants followed an isoenergenic low fat higher carbohydrate (HC) or higher protein (HP) diet while participating in a supervised 30-minute circuit resistance-training program three times per week for 14-weeks. In a randomized and double blind manner, participants ingested supplements containing 1,500 mg/d of glucosamine (as d-glucosamine HCL), 1,200 mg/d of chondroitin sulfate (from chondroitin sulfate sodium), and 900 mg/d of methylsulfonylmethane or a placebo. At 0, 10, and 14-weeks, participants completed a battery of assessments. Data were analyzed by MANOVA with repeated measures.
Results: Participants in both groups experienced significant reductions in body mass (-2.4 ± 3%), fat mass (-6.0 ± 6%), and body fat (-3.5 ± 4%) with no significant changes in fat free mass or resting energy expenditure. Perception of knee pain (-49 ± 39%) and knee stiffness (-42 ± 37%) was decreased while maximal strength (12%), muscular endurance (20%), balance indices (7% to 20%), lipid levels (-8% to -12%), homeostasis model assessment for estimating insulin resistance (-17%), leptin (-30%), and measures of physical functioning (59%), vitality (120%), and social function (66%) were improved in both groups with no differences among groups. Functional aerobic capacity was increased to a greater degree for those in the HP and GCM groups while there were some trends suggesting that supplementation affected perceptions of knee pain (p < 0.08).
Conclusions: Circuit style resistance-training and weight loss improved functional capacity in women with knee OA. The type of diet and dietary supplementation of GCM provided marginal additive benefits.
Trial registration: ClinicalTrials.gov: NCT01271218.
Figures
Figure 1
Participant flow diagram.
Figure 2
Changes in body composition variables among groups after 10 and 14 weeks of dieting and training.
Similar articles
- Chondroitin for osteoarthritis.
Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Singh JA, et al. Cochrane Database Syst Rev. 2015 Jan 28;1(1):CD005614. doi: 10.1002/14651858.CD005614.pub2. Cochrane Database Syst Rev. 2015. PMID: 25629804 Free PMC article. Review. - Effects of Adherence to a Higher Protein Diet on Weight Loss, Markers of Health, and Functional Capacity in Older Women Participating in a Resistance-Based Exercise Program.
Galbreath M, Campbell B, LaBounty P, Bunn J, Dove J, Harvey T, Hudson G, Gutierrez JL, Levers K, Galvan E, Jagim A, Greenwood L, Cooke MB, Greenwood M, Rasmussen C, Kreider RB. Galbreath M, et al. Nutrients. 2018 Aug 11;10(8):1070. doi: 10.3390/nu10081070. Nutrients. 2018. PMID: 30103509 Free PMC article. Clinical Trial. - A carbohydrate-restricted diet during resistance training promotes more favorable changes in body composition and markers of health in obese women with and without insulin resistance.
Kreider RB, Rasmussen C, Kerksick CM, Wilborn C, Taylor L 4th, Campbell B, Magrans-Courtney T, Fogt D, Ferreira M, Li R, Galbreath M, Iosia M, Cooke M, Serra M, Gutierrez J, Byrd M, Kresta JY, Simbo S, Oliver J, Greenwood M. Kreider RB, et al. Phys Sportsmed. 2011 May;39(2):27-40. doi: 10.3810/psm.2011.05.1893. Phys Sportsmed. 2011. PMID: 21673483 Clinical Trial. - Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Lubis AMT, et al. Acta Med Indones. 2017 Apr;49(2):105-111. Acta Med Indones. 2017. PMID: 28790224 Clinical Trial. - Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate.
Deal CL, Moskowitz RW. Deal CL, et al. Rheum Dis Clin North Am. 1999 May;25(2):379-95. doi: 10.1016/s0889-857x(05)70074-0. Rheum Dis Clin North Am. 1999. PMID: 10356424 Review.
Cited by
- Chondroitin for osteoarthritis.
Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Singh JA, et al. Cochrane Database Syst Rev. 2015 Jan 28;1(1):CD005614. doi: 10.1002/14651858.CD005614.pub2. Cochrane Database Syst Rev. 2015. PMID: 25629804 Free PMC article. Review. - Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence.
Colletti A, Cicero AFG. Colletti A, et al. Int J Mol Sci. 2021 Nov 29;22(23):12920. doi: 10.3390/ijms222312920. Int J Mol Sci. 2021. PMID: 34884724 Free PMC article. Review. - Dietary protein in weight management: a review proposing protein spread and change theories.
Bosse JD, Dixon BM. Bosse JD, et al. Nutr Metab (Lond). 2012 Sep 12;9(1):81. doi: 10.1186/1743-7075-9-81. Nutr Metab (Lond). 2012. PMID: 22971730 Free PMC article. - Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Obese Women.
Lockard B, Mardock M, Oliver JM, Byrd M, Simbo S, Jagim AR, Kresta J, Baetge CC, Jung YP, Koozehchian MS, Khanna D, Rasmussen C, Kreider RB. Lockard B, et al. Int J Environ Res Public Health. 2022 Apr 17;19(8):4877. doi: 10.3390/ijerph19084877. Int J Environ Res Public Health. 2022. PMID: 35457744 Free PMC article. Clinical Trial.
References
- Dillon CF, Rasch EK, Gu Q, Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94. J Rheumatol. 2006;33:2271–2279. - PubMed
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous