Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death - PubMed (original) (raw)
Review
. 2011 Jun 23;12(7):439-52.
doi: 10.1038/nrm3143.
Affiliations
- PMID: 21697901
- DOI: 10.1038/nrm3143
Review
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
Domagoj Vucic et al. Nat Rev Mol Cell Biol. 2011.
Abstract
The proper regulation of apoptosis is essential for the survival of multicellular organisms. Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia and graft rejection, and diminished apoptosis can lead to autoimmune diseases and cancer. It has become clear that the post-translational modification of apoptotic proteins by ubiquitylation regulates key components in cell death signalling cascades. For example, ubiquitin E3 ligases, such as MDM2 (which ubiquitylates p53) and inhibitor of apoptosis (IAP) proteins, and deubiquitinases, such as A20 and ubiquitin-specific protease 9X (USP9X) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (RIP1) and myeloid leukaemia cell differentiation 1 (MCL1), respectively), have important roles in apoptosis. Therapeutic agents that target apoptotic regulatory proteins, including those that are part of the ubiquitin-proteasome system, might afford clinical benefits.
Similar articles
- The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.
Weissman AM, Shabek N, Ciechanover A. Weissman AM, et al. Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):605-20. doi: 10.1038/nrm3173. Nat Rev Mol Cell Biol. 2011. PMID: 21860393 Free PMC article. Review. - Ubiquitination: Friend and foe in cancer.
Mansour MA. Mansour MA. Int J Biochem Cell Biol. 2018 Aug;101:80-93. doi: 10.1016/j.biocel.2018.06.001. Epub 2018 Jun 1. Int J Biochem Cell Biol. 2018. PMID: 29864543 Review. - Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
Lamsoul I, Uttenweiler-Joseph S, Moog-Lutz C, Lutz PG. Lamsoul I, et al. Biochimie. 2016 Mar;122:339-47. doi: 10.1016/j.biochi.2015.08.003. Epub 2015 Aug 4. Biochimie. 2016. PMID: 26253693 Review. - The Multifaceted Role of the Ubiquitin Proteasome System in Pathogenesis and Diseases.
Stekel Z, Sheng Y, Zhang W. Stekel Z, et al. Biomolecules. 2022 Jul 1;12(7):925. doi: 10.3390/biom12070925. Biomolecules. 2022. PMID: 35883481 Free PMC article. - Ubiquitylation of ABA Receptors and Protein Phosphatase 2C Coreceptors to Modulate ABA Signaling and Stress Response.
Coego A, Julian J, Lozano-Juste J, Pizzio GA, Alrefaei AF, Rodriguez PL. Coego A, et al. Int J Mol Sci. 2021 Jul 1;22(13):7103. doi: 10.3390/ijms22137103. Int J Mol Sci. 2021. PMID: 34281157 Free PMC article. Review.
Cited by
- Mmu-let-7a-5p inhibits macrophage apoptosis by targeting CASP3 to increase bacterial load and facilities mycobacterium survival.
Zhan X, Yuan W, Ma R, Zhou Y, Xu G, Ge Z. Zhan X, et al. PLoS One. 2024 Sep 3;19(9):e0308095. doi: 10.1371/journal.pone.0308095. eCollection 2024. PLoS One. 2024. PMID: 39226319 Free PMC article. - Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy.
Dakkak BE, Taneera J, El-Huneidi W, Abu-Gharbieh E, Hamoudi R, Semreen MH, Soares NC, Abu-Rish EY, Alkawareek MY, Alkilany AM, Bustanji Y. Dakkak BE, et al. Biomol Ther (Seoul). 2024 May 1;32(3):267-280. doi: 10.4062/biomolther.2023.149. Epub 2024 Apr 9. Biomol Ther (Seoul). 2024. PMID: 38589288 Free PMC article. Review. - OTUB1-mediated inhibition of ubiquitination: a growing list of effectors, multiplex mechanisms, and versatile functions.
Wu M, Sun L, Song T. Wu M, et al. Front Mol Biosci. 2024 Jan 9;10:1261273. doi: 10.3389/fmolb.2023.1261273. eCollection 2023. Front Mol Biosci. 2024. PMID: 38264570 Free PMC article. Review. - A20 haploinsufficiency in a neonate caused by a large deletion on chromosome 6q.
Zhang F, Zhang L. Zhang F, et al. Pediatr Rheumatol Online J. 2024 Jan 5;22(1):12. doi: 10.1186/s12969-023-00947-z. Pediatr Rheumatol Online J. 2024. PMID: 38183052 Free PMC article. Review. - Uncovering DUB Selectivity through an Ion Mobility-Based Assessment of Ubiquitin Chain Isomers.
Shestoperova EI, Strieter ER. Shestoperova EI, et al. Anal Chem. 2023 Nov 28;95(47):17416-17423. doi: 10.1021/acs.analchem.3c04622. Epub 2023 Nov 14. Anal Chem. 2023. PMID: 37962301 Free PMC article.
References
- Cell Death Differ. 2010 Jan;17(1):93-102 - PubMed
- PLoS Biol. 2010 Oct 26;8(10):e1000518 - PubMed
- Development. 2010 May;137(10):1679-88 - PubMed
- Nature. 2004 Apr 1;428(6982):1 p following 486 - PubMed
- J Biol Chem. 2002 Sep 27;277(39):36611-6 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous