The can and can't dos of p53 RNA - PubMed (original) (raw)
Review
. 2011 Nov;93(11):1962-5.
doi: 10.1016/j.biochi.2011.06.010. Epub 2011 Jun 23.
Affiliations
- PMID: 21722702
- DOI: 10.1016/j.biochi.2011.06.010
Review
The can and can't dos of p53 RNA
Marco M Candeias. Biochimie. 2011 Nov.
Abstract
The p53 protein, like any other protein, cannot be made in the cell without RNA. And even once made, the p53 protein will be more rapidly degraded without the p53 RNA. Furthermore, the p53 RNA helps deciding which p53 isoform should be produced and under which cell conditions. Mutant p53 mRNA codes for an unstable and inactive protein. These matters are discussed in this article as well as the recent reports on p53 RNA mutations, interacting-proteins, 3' processing and 5'-3' loop.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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