Molecular mechanism and physiological functions of clathrin-mediated endocytosis - PubMed (original) (raw)

Review

. 2011 Jul 22;12(8):517-33.

doi: 10.1038/nrm3151.

Affiliations

• PMID: 21779028
• DOI: 10.1038/nrm3151

Review

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

Harvey T McMahon et al. Nat Rev Mol Cell Biol. 2011.

Abstract

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life. Morphological stages of vesicle formation are mirrored by progression through various protein modules (complexes). The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating. Some modules can be used in other pathways, and additions or substitutions confer cell specificity and adaptability.

PubMed Disclaimer

Similar articles

• Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin.
  Zhao X, Greener T, Al-Hasani H, Cushman SW, Eisenberg E, Greene LE. Zhao X, et al. J Cell Sci. 2001 Jan;114(Pt 2):353-65. doi: 10.1242/jcs.114.2.353. J Cell Sci. 2001. PMID: 11148137
• Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis.
  Cheng X, Chen K, Dong B, Yang M, Filbrun SL, Myoung Y, Huang TX, Gu Y, Wang G, Fang N. Cheng X, et al. Nat Cell Biol. 2021 Aug;23(8):859-869. doi: 10.1038/s41556-021-00713-x. Epub 2021 Jul 12. Nat Cell Biol. 2021. PMID: 34253896 Free PMC article.
• Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis.
  Agrawal NJ, Nukpezah J, Radhakrishnan R. Agrawal NJ, et al. PLoS Comput Biol. 2010 Sep 9;6(9):e1000926. doi: 10.1371/journal.pcbi.1000926. PLoS Comput Biol. 2010. PMID: 20838575 Free PMC article.
• Regulation of Clathrin-Mediated Endocytosis.
  Mettlen M, Chen PH, Srinivasan S, Danuser G, Schmid SL. Mettlen M, et al. Annu Rev Biochem. 2018 Jun 20;87:871-896. doi: 10.1146/annurev-biochem-062917-012644. Epub 2018 Apr 16. Annu Rev Biochem. 2018. PMID: 29661000 Free PMC article. Review.
• The interplay between clathrin-coated vesicles and cell signalling.
  Mills IG. Mills IG. Semin Cell Dev Biol. 2007 Aug;18(4):459-70. doi: 10.1016/j.semcdb.2007.07.001. Epub 2007 Jul 6. Semin Cell Dev Biol. 2007. PMID: 17692542 Review.

Cited by

• Proximal Co-Translation Facilitates Detection of Weak Protein-Protein Interactions.
  Kordonsky A, Gabay M, Rosinoff A, Avishid R, Flornetin A, Deouell N, Abd Alkhaleq T, Efron N, Milshtein S, Shifman JM, Gal M, Prag G. Kordonsky A, et al. Int J Mol Sci. 2024 Oct 16;25(20):11099. doi: 10.3390/ijms252011099. Int J Mol Sci. 2024. PMID: 39456880 Free PMC article.
• Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains.
  Boucrot E, Pick A, Çamdere G, Liska N, Evergren E, McMahon HT, Kozlov MM. Boucrot E, et al. Cell. 2012 Mar 30;149(1):124-36. doi: 10.1016/j.cell.2012.01.047. Cell. 2012. PMID: 22464325 Free PMC article.
• ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
  Shah M, Baterina OY Jr, Taupin V, Farquhar MG. Shah M, et al. J Cell Biol. 2013 Jul 8;202(1):113-27. doi: 10.1083/jcb.201211110. J Cell Biol. 2013. PMID: 23836931 Free PMC article.
• The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
  Sorrentino V, Nelson JK, Maspero E, Marques ARA, Scheer L, Polo S, Zelcer N. Sorrentino V, et al. J Lipid Res. 2013 Aug;54(8):2174-2184. doi: 10.1194/jlr.M037713. Epub 2013 Jun 3. J Lipid Res. 2013. PMID: 23733886 Free PMC article.
• Regulation of membrane-shape transitions induced by I-BAR domains.
  Chen Z, Shi Z, Baumgart T. Chen Z, et al. Biophys J. 2015 Jul 21;109(2):298-307. doi: 10.1016/j.bpj.2015.06.010. Biophys J. 2015. PMID: 26200865 Free PMC article.

References

1. 1. J Cell Sci. 1999 Nov;112 ( Pt 22):3899-909 - PubMed
2. 1. Curr Biol. 1999 Mar 11;9(5):257-60 - PubMed
3. 1. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7939-44 - PubMed
4. 1. Nat Struct Mol Biol. 2011 Mar;18(3):295-301 - PubMed
5. 1. Curr Biol. 1998 Jun 18;8(13):740-9 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal