Breast cancer - one term, many entities? - PubMed (original) (raw)

Review

. 2011 Oct;121(10):3789-96.

doi: 10.1172/JCI57100. Epub 2011 Oct 3.

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Review

Breast cancer - one term, many entities?

Nicholas R Bertos et al. J Clin Invest. 2011 Oct.

Abstract

Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors with different clinical characteristics, disease courses, and responses to specific treatments. Tumor-intrinsic features, including classical histological and immunopathological classifications as well as more recently described molecular subtypes, separate breast tumors into multiple groups. Tumor-extrinsic features, including microenvironmental configuration, also have prognostic significance and further expand the list of tumor-defining variables. A better understanding of the features underlying heterogeneity, as well as of the mechanisms and consequences of their interactions, is essential to improve targeting of existing therapies and to develop novel agents addressing specific combinations of features.

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Figures

Figure 1

Figure 1. Schematic depiction of normal breast architecture and breast tumor and surrounding stroma, illustrating some of the tumor-intrinsic and microenvironmental variables contributing to disease heterogeneity.

(A) Normal breast architecture. (B) Breast tumor and surrounding stroma. TAM, tumor-associated macrophage.

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References

    1. Pinder SE, Ellis IO. The diagnosis and management of pre-invasive breast disease: ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH)--current definitions and classification. Breast Cancer Res. 2003;5(5):254–257. doi: 10.1186/bcr623. - DOI - PMC - PubMed
    1. Li CI, Uribe DJ, Daling JR. Clinical characteristics of different histologic types of breast cancer. Br J Cancer. 2005;93(9):1046–1052. doi: 10.1038/sj.bjc.6602787. - DOI - PMC - PubMed
    1. Weigelt B, Geyer FC, Reis-Filho JS. Histological types of breast cancer: how special are they? Mol Oncol. 2010;4(3):192–208. doi: 10.1016/j.molonc.2010.04.004. - DOI - PMC - PubMed
    1. Arpino G, Clark GM, Mohsin S, Bardou VJ, Elledge RM. Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome. Cancer. 2002;94(8):2119–2127. doi: 10.1002/cncr.10455. - DOI - PubMed
    1. Pedersen L, Zedeler K, Holck S, Schiodt T, Mouridsen HT. Medullary carcinoma of the breast. Prevalence and prognostic importance of classical risk factors in breast cancer. Eur J Cancer. 1995;31A(13–14):2289–2295. - PubMed

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