Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain - PubMed (original) (raw)

. 2011 Nov 18;415(2):330-6.

doi: 10.1016/j.bbrc.2011.10.056. Epub 2011 Oct 18.

Affiliations

• PMID: 22033402
• DOI: 10.1016/j.bbrc.2011.10.056

Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain

Inken Lorenzen et al. Biochem Biophys Res Commun. 2011.

Abstract

A disintegrin and metalloprotease protein 17 (ADAM17) is a transmembrane zinc dependent metalloprotease. The catalytic activity of the enzyme results in the shedding of a broad range of membrane proteins. The release of the corresponding ectodomains induces a switch in various physiological and pathophysiological processes. So far there is not much information about the molecular mechanism of ADAM17 activation available. As for other transmembrane proteases, multimerisation may play a critical role in the activation and function of ADAM17. The present work demonstrates that ADAM17 indeed exists as a multimer in the cell membrane and that this multimerisation is mediated by its EGF-like domain.

Copyright © 2011 Elsevier Inc. All rights reserved.

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