The Warburg effect in 2012 - PubMed (original) (raw)
Review
The Warburg effect in 2012
Jean-Pierre Bayley et al. Curr Opin Oncol. 2012 Jan.
Abstract
Purpose of review: A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.
Recent findings: The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors. Despite this setback, the reciprocal regulation of PKM2, prolyl hydroxylase 3 and HIF-1 in a positive feedback loop shows that PKM2 is important to tumor metabolism. Hexokinase II was reported to be a crucial regulator of glycolysis in glioblastoma multiforme, and the importance of lactate dehydrogenase was underlined by evidence that a 'lactate-based dialog' exists between cancer cells and endothelial cells. A growing appreciation of the role of oncogenes and tumor suppressor genes in the Warburg effect was reflected in reports of the regulation of glutamine metabolism by p53, the role of c-Myc in the high glucose uptake of tumors, and the regulation of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) and ATP consumption by AKT. The sirtuins, SIRT3 and SIRT6, were also shown to play central roles in aerobic glycolysis and other aspects of tumor metabolism.
Summary: The results discussed illustrate the growing integration of the previously distinct fields of molecular biological and metabolic cancer research and show that this synergy is beginning to yield a more complete and comprehensive understanding of the tumor cell.
Similar articles
- Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.
Mazurek S. Mazurek S. Int J Biochem Cell Biol. 2011 Jul;43(7):969-80. doi: 10.1016/j.biocel.2010.02.005. Epub 2010 Feb 13. Int J Biochem Cell Biol. 2011. PMID: 20156581 Review. - Mitochondria, hexokinase and pyruvate kinase isozymes in the aerobic glycolysis of tumor cells.
Petrucci D, Cesare P, Colafarina S. Petrucci D, et al. Ital J Biochem. 1997 Sep;46(3):131-41. Ital J Biochem. 1997. PMID: 9442422 - PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.
Dang CV. Dang CV. Sci Signal. 2009 Nov 17;2(97):pe75. doi: 10.1126/scisignal.297pe75. Sci Signal. 2009. PMID: 19920249 - Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H. Sun Q, et al. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15. Proc Natl Acad Sci U S A. 2011. PMID: 21325052 Free PMC article. - Acetylation control of metabolic enzymes in cancer: an updated version.
Huang W, Wang Z, Lei QY. Huang W, et al. Acta Biochim Biophys Sin (Shanghai). 2014 Mar;46(3):204-13. doi: 10.1093/abbs/gmt154. Epub 2014 Jan 30. Acta Biochim Biophys Sin (Shanghai). 2014. PMID: 24480802 Review.
Cited by
- Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.
Hitchler MJ, Domann FE. Hitchler MJ, et al. Free Radic Biol Med. 2012 Dec 1;53(11):2178-87. doi: 10.1016/j.freeradbiomed.2012.09.028. Epub 2012 Sep 26. Free Radic Biol Med. 2012. PMID: 23022407 Free PMC article. Review. - Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming.
Qie S, Liang D, Yin C, Gu W, Meng M, Wang C, Sang N. Qie S, et al. Cell Cycle. 2012 Oct 1;11(19):3679-90. doi: 10.4161/cc.21944. Epub 2012 Aug 30. Cell Cycle. 2012. PMID: 22935705 Free PMC article. - Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
He X, Zeng H, Chen JX. He X, et al. J Cell Physiol. 2019 Mar;234(3):2252-2265. doi: 10.1002/jcp.27200. Epub 2018 Aug 21. J Cell Physiol. 2019. PMID: 30132870 Free PMC article. Review. - Ovarian Cancer and Glutamine Metabolism.
Fasoulakis Z, Koutras A, Ntounis T, Prokopakis I, Perros P, Chionis A, Sapantzoglou I, Katrachouras A, Konis K, Samara AA, Valsamaki A, Palios VC, Symeonidis P, Nikolettos K, Pagkalos A, Sotiriou S, Theodora M, Antsaklis P, Daskalakis G, Kontomanolis EN. Fasoulakis Z, et al. Int J Mol Sci. 2023 Mar 6;24(5):5041. doi: 10.3390/ijms24055041. Int J Mol Sci. 2023. PMID: 36902470 Free PMC article. Review. - PKM2, function and expression and regulation.
Zhang Z, Deng X, Liu Y, Liu Y, Sun L, Chen F. Zhang Z, et al. Cell Biosci. 2019 Jun 26;9:52. doi: 10.1186/s13578-019-0317-8. eCollection 2019. Cell Biosci. 2019. PMID: 31391918 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous