Development of obesity and polycystic ovary syndrome in adolescents - PubMed (original) (raw)
Review
doi: 10.1159/000345310. Epub 2012 Nov 28.
Affiliations
- PMID: 23208318
- DOI: 10.1159/000345310
Free article
Review
Development of obesity and polycystic ovary syndrome in adolescents
Lea S Vilmann et al. Horm Res Paediatr. 2012.
Free article
Abstract
Obesity in adolescents is prevalent worldwide. Polycystic ovary syndrome (PCOS) is often associated with obesity in women, and it has serious metabolic and reproductive health implications. Although PCOS does not become clinically visible until early adolescence, its origins are likely much earlier. Therefore, we reviewed the recent literature regarding the mechanisms linking the development of PCOS and obesity in adolescent girls. We found that excess abdominal adipose tissue (AT) initiates metabolic and endocrine aberrations that are central in the progression of PCOS. As an example, abdominal AT impairs insulin action, which interacts with the progression of hyperandrogenism. In addition, excessive androgen levels lead to impaired glucose uptake, which also contributes to insulin resistance, which again increases the deposition of visceral fat. The body composition is influenced by testosterone, which decreases subcutaneous fat lipolysis and influences adipocyte distribution. These mechanisms may explain why PCOS girls have an increased visceral adipose mass independent of body mass index. Therefore, first-line treatment in adolescent PCOS is often lifestyle intervention to prevent the damaging effects of obesity. Pharmacological treatment of adolescent PCOS is not standardized because the long-term effects in adolescents have not yet been evaluated; therefore, drugs should be prescribed cautiously. Although the complex metabolic interrelationships between obesity and PCOS have yet to be fully understood, the co-occurrence of these conditions in adolescent girls tends to increase the severity of the negative health consequences of each condition.
Copyright © 2012 S. Karger AG, Basel.
Similar articles
- Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk.
Rees E, Coulson R, Dunstan F, Evans WD, Blundell HL, Luzio SD, Dunseath G, Halcox JP, Fraser AG, Rees DA. Rees E, et al. Hum Reprod. 2014 Sep;29(9):2041-9. doi: 10.1093/humrep/deu180. Epub 2014 Jul 17. Hum Reprod. 2014. PMID: 25035436 - Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models.
Caldwell AS, Middleton LJ, Jimenez M, Desai R, McMahon AC, Allan CM, Handelsman DJ, Walters KA. Caldwell AS, et al. Endocrinology. 2014 Aug;155(8):3146-59. doi: 10.1210/en.2014-1196. Epub 2014 May 30. Endocrinology. 2014. PMID: 24877633 - Role of obesity and adiposity in polycystic ovary syndrome.
Diamanti-Kandarakis E. Diamanti-Kandarakis E. Int J Obes (Lond). 2007 Nov;31 Suppl 2:S8-13; discussion S31-2. doi: 10.1038/sj.ijo.0803730. Int J Obes (Lond). 2007. PMID: 17968437 Review. - Polycystic Ovary Syndrome in Adolescents.
Witchel SF, Roumimper H, Oberfield S. Witchel SF, et al. Endocrinol Metab Clin North Am. 2016 Jun;45(2):329-44. doi: 10.1016/j.ecl.2016.01.004. Epub 2016 Apr 1. Endocrinol Metab Clin North Am. 2016. PMID: 27241968 Review.
Cited by
- Prevalence of Polycystic Ovary Syndrome (PCOS) and Its Associated Risk Factors among Medical Students in Two Countries.
Begum GS, Almashaikhi NAT, Albalushi MY, Alsalehi HM, Alazawi RS, Goud BKM, Dube R. Begum GS, et al. Int J Environ Res Public Health. 2024 Sep 2;21(9):1165. doi: 10.3390/ijerph21091165. Int J Environ Res Public Health. 2024. PMID: 39338048 Free PMC article. - Irregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort.
Wang Z, Jukic AMZ, Baird DD, Wilcox AJ, Li H, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S. Wang Z, et al. JAMA Netw Open. 2024 May 1;7(5):e249657. doi: 10.1001/jamanetworkopen.2024.9657. JAMA Netw Open. 2024. PMID: 38700861 Free PMC article. - Obesity and its impact on female reproductive health: unraveling the connections.
Zheng L, Yang L, Guo Z, Yao N, Zhang S, Pu P. Zheng L, et al. Front Endocrinol (Lausanne). 2024 Jan 9;14:1326546. doi: 10.3389/fendo.2023.1326546. eCollection 2023. Front Endocrinol (Lausanne). 2024. PMID: 38264286 Free PMC article. Review. - Prevalence of Polycystic Ovarian Syndrome and Its Link to Obesity in Adolescent Girls.
Aggarwal M, Chakole S. Aggarwal M, et al. Cureus. 2023 Sep 17;15(9):e45405. doi: 10.7759/cureus.45405. eCollection 2023 Sep. Cureus. 2023. PMID: 37854752 Free PMC article. Review. - Acyl-Carnitines Exert Positive Effects on Mitochondrial Activity under Oxidative Stress in Mouse Oocytes: A Potential Mechanism Underlying Carnitine Efficacy on PCOS.
Placidi M, Vergara T, Casoli G, Flati I, Capece D, Artini PG, Virmani A, Zanatta S, D'Alessandro AM, Tatone C, Di Emidio G. Placidi M, et al. Biomedicines. 2023 Sep 6;11(9):2474. doi: 10.3390/biomedicines11092474. Biomedicines. 2023. PMID: 37760915 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials