Race and gender variation in response to evoked inflammation - PubMed (original) (raw)

doi: 10.1186/1479-5876-11-63.

Parth N Patel, Rhia Y Shah, Claire K Mulvey, Ram Gadi, Prabhjot S Nijjar, Haris M Usman, Nehal N Mehta, Rachana Shah, Stephen R Master, Kathleen J Propert, Muredach P Reilly

Affiliations

Race and gender variation in response to evoked inflammation

Jane F Ferguson et al. J Transl Med. 2013.

Abstract

Background: Race- and gender-variation in innate immunity may contribute to demographic differences in inflammatory and cardiometabolic disease; yet their influence on dynamic responses during inflammatory stress is poorly understood. Our objective was to examine race and gender influence on the response to experimental endotoxemia.

Methods: The Genetics of Evoked Responses to Niacin and Endotoxemia (GENE) study was designed to investigate regulation of inflammatory and metabolic responses during low-grade endotoxemia (LPS 1 ng/kg intravenously) in healthy individuals (median age 24, IQR=7) of European (EA; n=193, 47% female) and African ancestry (AA; n=101, 59% female).

Results: Baseline clinical, metabolic, and inflammatory biomarkers by race and gender were consistent with epidemiological literature; pre-LPS cytokines (e.g. median (IQR) IL-6, 2.7 (2) vs.2.1 (2) pg/ml, P=0.001) were higher in AA than EA. In contrast, acute cytokine responses during endotoxemia were lower in AA than EA (e.g. median (IQR) peak IL-1RA, 30 (38) vs.43 (45) ng/ml P=0.002) as was the induction of hepatic acute-phase proteins (e.g. median (IQR) peak CRP 12.9 (9) vs.17.4 (12) mg/L P=0.005). Further, baseline levels of cytokines were only weakly correlated with peak inflammatory responses (all r(s) <0.2) both in AA and in EA. There were less pronounced and less consistent differences in the response by gender, with males having a higher AUC for CRP response compared to females (median (IQR) AUC: 185 (112) vs. 155 (118), P=0.02).

Conclusions: We observed lower levels of evoked inflammation in response to endotoxin in AA compared with EA, despite similar or higher baseline levels of inflammatory markers in AA. Our data also suggest that levels of inflammatory biomarkers measured in epidemiological settings might not predict the degree of acute stress-response or risk of diseases characterized by activation of innate immunity.

Trial registration: FDA clinicaltrials.gov registration number NCT00953667.

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Figures

Figure 1

Figure 1

Design of the genetics of evoked responses to niacin and endotoxemia study. Healthy volunteers of European and African ancestry participated in the Genetics of Evoked Responses to Niacin and Endotoxemia (GENE) Study. Results are presented here for the 294 individuals that participated in the GENE-LPS component of the study.

Figure 2

Figure 2

Race and gender influence on circulating inflammatory biomarker responses to endotoxemia. European ancestry participants have a higher peak inflammatory response than African ancestry individuals for (A) IL-6, (B) TNFα, (C) IL-1RA, (D) CRP, and (E) SAA.

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References

    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867. doi: 10.1038/nature05485. - DOI - PubMed
    1. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695. doi: 10.1056/NEJMra043430. - DOI - PubMed
    1. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123:e18–e209. doi: 10.1161/CIR.0b013e3182009701. - DOI - PMC - PubMed
    1. Mayr FB, Yende S, Linde-Zwirble WT, Peck-Palmer OM, Barnato AE, Weissfeld LA, Angus DC. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA. 2010;303:2495–2503. doi: 10.1001/jama.2010.851. - DOI - PMC - PubMed
    1. Adrie C, Azoulay E, Francais A, Clec’h C, Darques L, Schwebel C, Nakache D, Jamali S, Goldgran-Toledano D, Garrouste-Orgeas M, Timsit JF. Influence of gender on the outcome of severe sepsis: a reappraisal. Chest. 2007;132:1786–1793. doi: 10.1378/chest.07-0420. - DOI - PubMed

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