Distribution of blood-brain barrier disruption in primary blast injury - PubMed (original) (raw)
. 2013 Oct;41(10):2206-14.
doi: 10.1007/s10439-013-0805-7. Epub 2013 Apr 9.
Affiliations
- PMID: 23568152
- DOI: 10.1007/s10439-013-0805-7
Distribution of blood-brain barrier disruption in primary blast injury
Stewart Yeoh et al. Ann Biomed Eng. 2013 Oct.
Abstract
Traumatic brain injury (TBI) resulting from explosive-related blast overpressure is a topic at the forefront of neurotrauma research. Compromise of the blood-brain barrier (BBB) and other cerebral blood vessel dysfunction is commonly reported in both experimental and clinical studies on blast injury. This study used a rifle primer-driven shock tube to investigate cerebrovascular injury in rats exposed to low-impulse, pure primary blast at three levels of overpressure (145, 232, and 323 kPa) and with three survival times (acute, 24, and 48 h). BBB disruption was quantified immunohistochemically by measuring immunoglobulin G (IgG) extravasation with image analysis techniques. Pure primary blast generated small lesions scattered throughout the brain. The number and size of lesions increased with peak overpressure level, but no significant difference was seen between survival times. Despite laterally directed blast exposure, equal numbers of lesions were found in each hemisphere of the brain. These observations suggest that cerebrovascular injury due to primary blast is distinct from that associated with conventional TBI.
Similar articles
- Blast traumatic brain injury in the rat using a blast overpressure model.
Yarnell AM, Shaughness MC, Barry ES, Ahlers ST, McCarron RM, Grunberg NE. Yarnell AM, et al. Curr Protoc Neurosci. 2013;Chapter 9:Unit 9.41. doi: 10.1002/0471142301.ns0941s62. Curr Protoc Neurosci. 2013. PMID: 23315947 - Survival risk assessment for primary blast exposures to the head.
Rafaels K, Bass CR, Salzar RS, Panzer MB, Woods W, Feldman S, Cummings T, Capehart B. Rafaels K, et al. J Neurotrauma. 2011 Nov;28(11):2319-28. doi: 10.1089/neu.2009.1207. Epub 2011 May 16. J Neurotrauma. 2011. PMID: 21463161 - Repeated primary blast injury causes delayed recovery, but not additive disruption, in an in vitro blood-brain barrier model.
Hue CD, Cao S, Dale Bass CR, Meaney DF, Morrison B 3rd. Hue CD, et al. J Neurotrauma. 2014 May 15;31(10):951-60. doi: 10.1089/neu.2013.3149. Epub 2014 Feb 20. J Neurotrauma. 2014. PMID: 24372353 - Blast related neurotrauma: a review of cellular injury.
Leung LY, VandeVord PJ, Dal Cengio AL, Bir C, Yang KH, King AI. Leung LY, et al. Mol Cell Biomech. 2008 Sep;5(3):155-68. Mol Cell Biomech. 2008. PMID: 18751525 Review. - Blast-induced brain injury and posttraumatic hypotension and hypoxemia.
DeWitt DS, Prough DS. DeWitt DS, et al. J Neurotrauma. 2009 Jun;26(6):877-87. doi: 10.1089/neu.2007.0439. J Neurotrauma. 2009. PMID: 18447627 Review.
Cited by
- Twenty Years of Blast-Induced Neurotrauma: Current State of Knowledge.
Sachdeva T, Ganpule SG. Sachdeva T, et al. Neurotrauma Rep. 2024 Mar 14;5(1):243-253. doi: 10.1089/neur.2024.0001. eCollection 2024. Neurotrauma Rep. 2024. PMID: 38515548 Free PMC article. - Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging.
Kilgore MO, Hubbard WB. Kilgore MO, et al. Int J Mol Sci. 2024 Jan 4;25(1):642. doi: 10.3390/ijms25010642. Int J Mol Sci. 2024. PMID: 38203813 Free PMC article. Review. - Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review.
Zhao ZA, Yan L, Wen J, Satyanarayanan SK, Yu F, Lu J, Liu YU, Su H. Zhao ZA, et al. Burns Trauma. 2023 Sep 4;11:tkad033. doi: 10.1093/burnst/tkad033. eCollection 2023. Burns Trauma. 2023. PMID: 37675267 Free PMC article. Review. - Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice.
Li C, Chen S, Siedhoff HR, Grant D, Liu P, Balderrama A, Jackson M, Zuckerman A, Greenlief CM, Kobeissy F, Wang KW, DePalma RG, Cernak I, Cui J, Gu Z. Li C, et al. Acta Neuropathol Commun. 2023 Sep 6;11(1):144. doi: 10.1186/s40478-023-01636-4. Acta Neuropathol Commun. 2023. PMID: 37674234 Free PMC article. - Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures.
Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, Kawoos U, Hogg S, Ache B, Sowa A, Tetreault T, Varghese M, Cook DG, Zhu CW, Tappan SJ, Janssen WGM, Hof PR, Ahlers ST, Elder GA. Gama Sosa MA, et al. Acta Neuropathol Commun. 2023 May 12;11(1):81. doi: 10.1186/s40478-023-01553-6. Acta Neuropathol Commun. 2023. PMID: 37173747 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials