Signal-dependent Elk-1 target genes involved in transcript processing and cell migration - PubMed (original) (raw)

Review

. 2013 Oct;1829(10):1026-33.

doi: 10.1016/j.bbagrm.2013.05.004. Epub 2013 May 24.

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Review

Signal-dependent Elk-1 target genes involved in transcript processing and cell migration

Aneta Kasza. Biochim Biophys Acta. 2013 Oct.

Abstract

Elk-1 was regarded as a transcription factor engaged mainly in the regulation of cell growth, differentiation, and survival. Recent findings show the engagement of Elk-1 in the control of expression of genes encoding proteins involved in transcript turnover, such as MCPIP1/ZC3H12A and tristetraprolin (TTP/ZFP36). Thus, Elk-1 plays an important role in the control of gene expression not only through the stimulation of expression of transcription factors, but also through regulation of transcript half-live. Moreover, Elk-1 is engaged in the regulation of expression of genes encoding proteins that control proteolytic activity, such as inhibitor of plasminogen activator-1 (PAI-1) and metalloproteinases-2 and -9 (MMP-2 and MMP-9). This review summarizes the biological roles of proteins with expression regulated by Elk-1, involved in transcripts turnover or in cell migration. The broad range of function of these proteins illustrates the complex role of Elk-1 in the regulation of cancer and inflammation.

Keywords: Cancer; Elk-1; MCPIP1; MMPs; PAI-1; Tristetraprolin.

Copyright © 2013 Elsevier B.V. All rights reserved.

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