Bringing genome-wide association findings into clinical use - PubMed (original) (raw)

Review

doi: 10.1038/nrg3523. Epub 2013 Jul 9.

Affiliations

Review

Bringing genome-wide association findings into clinical use

Teri A Manolio. Nat Rev Genet. 2013 Aug.

Abstract

Genome-wide association studies (GWASs) have been heralded as a major advance in biomedical discovery, having identified ~2,000 robust associations with complex diseases since 2005. Despite this success, they have met considerable scepticism regarding their clinical applicability; this scepticism arises from such aspects as the modest effect sizes of associated variants and their unclear functional consequences. There are, however, promising examples of GWAS findings that will or that may soon be translated into clinical care. These examples include variants identified through GWASs that provide strongly predictive or prognostic information or that have important pharmacological implications; these examples may illustrate promising approaches to wider clinical application.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Am Heart J. 2009 Jul;158(1):105-10 - PubMed
    1. Arch Gen Psychiatry. 2012 Sep;69(9):904-12 - PubMed
    1. Diabetologia. 2011 Nov;54(11):2801-10 - PubMed
    1. Trends Mol Med. 2011 May;17(5):244-51 - PubMed
    1. JAMA. 2003 Apr 2;289(13):1681-90 - PubMed

Publication types

MeSH terms

LinkOut - more resources