Andirolides Q-V from the flower of andiroba (Carapa guianensis, Meliaceae) - PubMed (original) (raw)
Andirolides Q-V from the flower of andiroba (Carapa guianensis, Meliaceae)
Asami Sakamoto et al. Fitoterapia. 2013 Oct.
Abstract
Two new gedunins, an andirobin, two mexicanolides, and a phragmalin-type limonoid, named Andirolides Q (1), R (2), S (3), T (4), U (5), and V (6), were isolated from an oil of the flower of Carapa guianensis AUBLET (Meliaceae). Their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR spectra and FABMS. Andirolide S (3) and Andirolide T (4) showed significant cytotoxic activity against the murine P388 leukemia cell line (IC₅₀ of 1.4 μM for 3; 1.8 μM for 4) and the human HL-60 leukemia cell line (IC₅₀ of 1.3 μM for 3 and 4).
Keywords: Andirolides Q–V; Carapa guianensis; Human HL-60 leukemia cell line; Limonoid; Murine P388 leukemia cell line.
© 2013.
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