Inflammasome and atherogenesis - PubMed (original) (raw)

Review

Inflammasome and atherogenesis

Xinjie Lu et al. Curr Pharm Des. 2014.

Abstract

Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. Inflammation and the innate immune response are involved in the formation of early atherosclerotic lesion. A protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are responsible for activation of inflammatory processes. Inflammasome-mediated processes are important in the process of atherosclerosis. The front of structure domains as well as IL-1, and IL-18 stands at the threshold of the adaptive immune response that accelerates full-blown atherosclerotic disease progression. This review is intended to provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for therapy of this disease.

PubMed Disclaimer

Similar articles

• Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition.
  Ma S, Chen J, Feng J, Zhang R, Fan M, Han D, Li X, Li C, Ren J, Wang Y, Cao F. Ma S, et al. Oxid Med Cell Longev. 2018 Sep 4;2018:9286458. doi: 10.1155/2018/9286458. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30254716 Free PMC article.
• Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy.
  Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, Kim DJ, Jeong KH, Lee TW, Ihm CG, Won KY, Moon JY. Kim SM, et al. Am J Physiol Renal Physiol. 2015 May 1;308(9):F993-F1003. doi: 10.1152/ajprenal.00637.2014. Epub 2015 Jan 28. Am J Physiol Renal Physiol. 2015. PMID: 25651569
• β2-glycoprotein I and oxidative inflammation in early atherogenesis: a progression from innate to adaptive immunity?
  Matsuura E, Lopez LR, Shoenfeld Y, Ames PR. Matsuura E, et al. Autoimmun Rev. 2012 Dec;12(2):241-9. doi: 10.1016/j.autrev.2012.04.003. Epub 2012 Apr 27. Autoimmun Rev. 2012. PMID: 22569463 Review.
• Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis.
  Tumurkhuu G, Shimada K, Dagvadorj J, Crother TR, Zhang W, Luthringer D, Gottlieb RA, Chen S, Arditi M. Tumurkhuu G, et al. Circ Res. 2016 Sep 2;119(6):e76-90. doi: 10.1161/CIRCRESAHA.116.308362. Epub 2016 Jul 6. Circ Res. 2016. PMID: 27384322 Free PMC article.
• The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.
  Martínez GJ, Celermajer DS, Patel S. Martínez GJ, et al. Atherosclerosis. 2018 Feb;269:262-271. doi: 10.1016/j.atherosclerosis.2017.12.027. Epub 2017 Dec 25. Atherosclerosis. 2018. PMID: 29352570 Review.

Cited by

• Secretory leukocyte protease inhibitor promising protective roles in obesity-associated atherosclerosis.
  Zhong QQ, Wang X, Li YF, Peng LJ, Jiang ZS. Zhong QQ, et al. Exp Biol Med (Maywood). 2017 Feb;242(3):250-257. doi: 10.1177/1535370216672747. Epub 2016 Oct 4. Exp Biol Med (Maywood). 2017. PMID: 27698252 Free PMC article. Review.
• The Enhanced Pharmacological Effects of Modified Traditional Chinese Medicine in Attenuation of Atherosclerosis Is Driven by Modulation of Gut Microbiota.
  Ji W, Jiang T, Sun Z, Teng F, Ma C, Huang S, Yan S. Ji W, et al. Front Pharmacol. 2020 Oct 15;11:546589. doi: 10.3389/fphar.2020.546589. eCollection 2020. Front Pharmacol. 2020. PMID: 33178012 Free PMC article.
• The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis.
  Yu M, Tsai SF, Kuo YM. Yu M, et al. Int J Mol Sci. 2017 Jun 13;18(6):1260. doi: 10.3390/ijms18061260. Int J Mol Sci. 2017. PMID: 28608819 Free PMC article. Review.
• NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.
  Zhao X, Gu C, Yan C, Zhang X, Li Y, Wang L, Ren L, Zhang Y, Peng J, Zhu Z, Han Y. Zhao X, et al. Biomed Res Int. 2016;2016:7395627. doi: 10.1155/2016/7395627. Epub 2016 Jun 30. Biomed Res Int. 2016. PMID: 27446957 Free PMC article.
• Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis.
  Lee J, Wan J, Lee L, Peng C, Xie H, Lee C. Lee J, et al. Lipids Health Dis. 2017 Nov 18;16(1):217. doi: 10.1186/s12944-017-0595-2. Lipids Health Dis. 2017. PMID: 29151018 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Bentham Science Publishers Ltd.
  • Ingenta plc

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal