Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters - PubMed (original) (raw)
doi: 10.1016/j.radonc.2013.08.031. Epub 2013 Sep 14.
Wouter van Elmpt, Roel Wierts, Bart Reymen, Hoda Sharifi, Michel C Öllers, Frank Hoebers, Esther G C Troost, Rinus Wanders, Angela van Baardwijk, Boudewijn Brans, Jonas Eriksson, Bert Windhorst, Felix M Mottaghy, Dirk De Ruysscher, Philippe Lambin
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- PMID: 24044790
- DOI: 10.1016/j.radonc.2013.08.031
Free article
Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters
Catharina M L Zegers et al. Radiother Oncol. 2013 Oct.
Free article
Abstract
Background and purpose: [(18)F]HX4 is a promising hypoxia PET-tracer. Uptake, spatio-temporal stability and optimal acquisition parameters for [(18)F]HX4 PET imaging were evaluated in non-small cell lung cancer (NSCLC) patients.
Materials and methods: [(18)F]HX4 PET/CT images of 15 NSCLC patients were acquired 2h and 4h after injection (p.i.). Maximum standardized-uptake-value (SUV(max)), tumor-to-blood-ratio (TBR(max)), hypoxic fraction (HF) and contrast-to-noise-ratio (CNR) were determined for all lesions. To evaluate spatio-temporal stability, DICE-similarity and Pearson correlation coefficients were calculated. Optimal acquisition-duration was assessed by comparing 30, 20, 10 and 5 min acquisitions.
Results: Considerable uptake (TBR >1.4) was observed in 18/25 target lesions. TBR(max) increased significantly from 2 h (1.6 ± 0.3) to 4 h p.i. (2.0 ± 0.6). Uptake patterns at 2 h and 4 h p.i. showed a strong correlation (R=0.77 ± 0.10) with a DICE similarity coefficient of 0.69 ± 0.08 for the 30% highest uptake volume. Reducing acquisition-time resulted in significant changes in SUV(max) and CNR. TBR(max) and HF were only affected for scan-times of 5 min.
Conclusions: The majority of NSCLC lesions showed considerable [(18)F]HX4 uptake. The heterogeneous uptake pattern was stable between 2 h and 4 h p.i. [(18)F]HX4 PET imaging at 4 h p.i. is superior to 2 h p.i. to reach highest contrast. Acquisition time may be reduced to 10 min without significant effects on TBR(max) and HF.
Keywords: HX4; Hypoxia; Imaging; NSCLC; PET.
Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
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