Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus - PubMed (original) (raw)
. 2013 Winter;18(1):e44-6.
Affiliations
- PMID: 24294048
- PMCID: PMC3716502
Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus
Marcelo Utrera-Lagunas et al. Exp Clin Cardiol. 2013 Winter.
Abstract
Background: Diabetes is a major risk factor for heart failure (HF), although the pathophysiological processes have not been clarified.
Objective: To determine the prevalence of HF and of abnormal myocardial perfusion in diabetic patients evaluated using technetium (99m) sestamibi single-photon emission computed tomography.
Methods: An observational cross-sectional study was conducted that included patients with type 2 diabetes mellitus who underwent echocardiography to diagnose HF and a pharmacological stress test with intravenous dipyridamole to examine cardiac scintigraphic perfusion abnormalities. Clinical and biochemical data were also collected.
Results: Of the 160 diabetic patients included, 92 (57.6%) were in HF and 68 (42.5%) were not. When patients were stratified according to the presence of abnormal myocardial perfusion, those with abnormal perfusion had a higher prevalence of HF (93%) than those with normal perfusion (44.4%) (P<0.0001). Patients with HF weighed more (P=0.03), used insulin less frequently (P=0.01), had lower total cholesterol (P=0.05) and high-density lipoprotein cholesterol concentrations (P=0.002), and a greater number of their myocardial segments showed abnormal perfusion (P≤0.001). More HF patients had a history of myocardial infarction (P<0.001) compared with those without HF. In a logistic regression analysis, the number of segments exhibiting abnormal myocardial perfusion was an independent risk factor for HF.
Conclusions: The prevalence of HF in diabetic patients was high and HF predominantly occured in association with myocardial ischemia.
Keywords: Diabetes mellitus; Heart failure; Myocardial perfusion.
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References
- Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal Diabetes control in type 2 diabetic patients. Diabetes Care. 2000;23(Suppl 2):B21–B29. - PubMed
- Leung AA, Eurich DT, Lamb DA, et al. Risk of HF in patients with recent-onset type 2 diabetes: Population-based cohort study. J Cardiac Fail. 2009;15:152–7. - PubMed
- MacDonald MR, Petrie MC, Hawkins NM, et al. Diabetes, left ventricular systolic dysfunction, and chronic HF. Eur Heart J. 2008;29:1224–40. - PubMed
- Bertoni G, Hundley G, Massing M, Bonds D, Burke G, Goff D. HF prevalence, incidence, and mortality in the elderly with diabetes. Diabetes Care. 2004;27:699–703. - PubMed
- Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive HF in type 2 diabetes: Prevalence, incidence, and risk factors. Diabetes Care. 2001;24:1614–9. - PubMed
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