Dimethyl sulfoxide inhibits NLRP3 inflammasome activation - PubMed (original) (raw)
. 2014 Apr;219(4):315-22.
doi: 10.1016/j.imbio.2013.11.003. Epub 2013 Nov 22.
Affiliations
- PMID: 24380723
- DOI: 10.1016/j.imbio.2013.11.003
Dimethyl sulfoxide inhibits NLRP3 inflammasome activation
Huijeong Ahn et al. Immunobiology. 2014 Apr.
Abstract
Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is commonly/widely used as a solvent for biological compounds. In addition, DMSO has been studied as a medication for the treatment of inflammation, cystitis, and arthritis. Based on the anti-inflammatory characteristics of DMSO, we elucidated the effects of DMSO on activation of inflammasomes, which are cytoplasmic multi-protein complexes that mediate the maturation of interleukin (IL)-1β by activating caspase-1 (Casp1). In the present study, we prove that DMSO attenuated IL-1β maturation, Casp1 activity, and ASC pyroptosome formation via NLRP3 inflammasome activators. Further, NLRC4 and AIM2 inflammasome activity were not affected, suggesting that DMSO is a selective inhibitor of the NLRP3 inflammasomes. The anti-inflammatory effect of DMSO was further confirmed in animal, LPS-endotoxin sepsis and inflammatory bowel disease models. In addition, DMSO inhibited LPS-mediating IL-1s transcription. Taken together, DMSO shows anti-inflammatory characteristics, attenuates NLRP3 inflammasome activation, and mediates inhibition of IL-1s transcription.
Keywords: Cytokine; DMSO; Inflammasome; Interleukin-1; Macrophages; NLRP3.
Crown Copyright © 2013. Published by Elsevier GmbH. All rights reserved.
Comment in
- Effects of dimethyl sulfoxide on the NLRP3 inflammasome.
Marchetti C, Mezzaroma E, Toldo S. Marchetti C, et al. Immunobiology. 2015 Aug;220(8):1030. doi: 10.1016/j.imbio.2015.02.003. Epub 2015 Feb 23. Immunobiology. 2015. PMID: 25743943 No abstract available.
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