Hippocampal synaptic plasticity, spatial memory and anxiety - PubMed (original) (raw)

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doi: 10.1038/nrn3677.

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• PMID: 24552786
• DOI: 10.1038/nrn3677

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Review

Hippocampal synaptic plasticity, spatial memory and anxiety

David M Bannerman et al. Nat Rev Neurosci. 2014 Mar.

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Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

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