Waiting list may be a nocebo condition in psychotherapy trials: a contribution from network meta-analysis - PubMed (original) (raw)
Meta-Analysis
. 2014 Sep;130(3):181-92.
doi: 10.1111/acps.12275. Epub 2014 Apr 4.
Affiliations
- PMID: 24697518
- DOI: 10.1111/acps.12275
Meta-Analysis
Waiting list may be a nocebo condition in psychotherapy trials: a contribution from network meta-analysis
T A Furukawa et al. Acta Psychiatr Scand. 2014 Sep.
Abstract
Objective: Various control conditions have been employed in psychotherapy trials, but there is growing suspicion that they may lead to different effect size estimates. The present study aims to examine the differences among control conditions including waiting list (WL), no treatment (NT) and psychological placebo (PP).
Method: We comprehensively searched for all randomized controlled trials (RCTs) comparing cognitive-behaviour therapies (CBT) against various control conditions in the acute phase treatment of depression, and applied network meta-analysis (NMA) to combine all direct and indirect comparisons among the treatment and control arms.
Results: We identified 49 RCTs (2730 participants) comparing WL, NT, PP and CBT. This network of evidence was consistent, and the effect size estimates for CBT were substantively different depending on the control condition. The odds ratio of response for NT over WL was statistically significant at 2.9 (95% CI: 1.3-5.7). However, the quality of evidence, including publication bias, was less than ideal and none of the preplanned sensitivity analyses limiting to high-quality studies could be conducted, while findings of significant differences did not persist in post hoc sensitivity analyses trying to adjust for publication bias.
Conclusion: There may be important differences in control conditions currently used in psychotherapy trials.
Keywords: clinical trials; cognitive therapy; control groups; placebo; waiting lists.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
- Behavioural activation therapy for depression in adults.
Uphoff E, Ekers D, Robertson L, Dawson S, Sanger E, South E, Samaan Z, Richards D, Meader N, Churchill R. Uphoff E, et al. Cochrane Database Syst Rev. 2020 Jul 6;7(7):CD013305. doi: 10.1002/14651858.CD013305.pub2. Cochrane Database Syst Rev. 2020. PMID: 32628293 Free PMC article. - 'Third wave' cognitive and behavioural therapies versus treatment as usual for depression.
Churchill R, Moore TH, Furukawa TA, Caldwell DM, Davies P, Jones H, Shinohara K, Imai H, Lewis G, Hunot V. Churchill R, et al. Cochrane Database Syst Rev. 2013 Oct 18;(10):CD008705. doi: 10.1002/14651858.CD008705.pub2. Cochrane Database Syst Rev. 2013. PMID: 24142810 Review. - Non-pharmacological interventions for somatoform disorders and medically unexplained physical symptoms (MUPS) in adults.
van Dessel N, den Boeft M, van der Wouden JC, Kleinstäuber M, Leone SS, Terluin B, Numans ME, van der Horst HE, van Marwijk H. van Dessel N, et al. Cochrane Database Syst Rev. 2014 Nov 1;2014(11):CD011142. doi: 10.1002/14651858.CD011142.pub2. Cochrane Database Syst Rev. 2014. PMID: 25362239 Free PMC article. Review. - Present-centered therapy (PCT) for post-traumatic stress disorder (PTSD) in adults.
Belsher BE, Beech E, Evatt D, Smolenski DJ, Shea MT, Otto JL, Rosen CS, Schnurr PP. Belsher BE, et al. Cochrane Database Syst Rev. 2019 Nov 18;2019(11):CD012898. doi: 10.1002/14651858.CD012898.pub2. Cochrane Database Syst Rev. 2019. PMID: 31742672 Free PMC article. - The overestimation of the effect sizes of psychotherapies for depression in waitlist controlled trials: a meta-analytic comparison with usual care controlled trials.
Cuijpers P, Miguel C, Harrer M, Ciharova M, Karyotaki E. Cuijpers P, et al. Epidemiol Psychiatr Sci. 2024 Nov 6;33:e56. doi: 10.1017/S2045796024000611. Epidemiol Psychiatr Sci. 2024. PMID: 39501660 Free PMC article.
Cited by
- Two decades of digital interventions for anxiety disorders: a systematic review and meta-analysis of treatment effectiveness.
Pauley D, Cuijpers P, Papola D, Miguel C, Karyotaki E. Pauley D, et al. Psychol Med. 2023 Jan;53(2):567-579. doi: 10.1017/S0033291721001999. Epub 2021 May 28. Psychol Med. 2023. PMID: 34047264 Free PMC article. - Is psychotherapy effective? A re-analysis of treatments for depression.
Munder T, Flückiger C, Leichsenring F, Abbass AA, Hilsenroth MJ, Luyten P, Rabung S, Steinert C, Wampold BE. Munder T, et al. Epidemiol Psychiatr Sci. 2019 Jun;28(3):268-274. doi: 10.1017/S2045796018000355. Epub 2018 Jul 30. Epidemiol Psychiatr Sci. 2019. PMID: 30058524 Free PMC article. - A tailored Internet-delivered modular intervention based on cognitive behavioral therapy for depressed older adults: a study protocol for a randomized controlled trial.
Eimontas J, Pakalniškienė V, Biliunaite I, Andersson G. Eimontas J, et al. Trials. 2021 Dec 16;22(1):925. doi: 10.1186/s13063-021-05903-4. Trials. 2021. PMID: 34915909 Free PMC article. - Optimization of smartphone psychotherapy for depression and anxiety among patients with cancer using the multiphase optimization strategy (MOST) framework and decentralized clinical trial system (SMartphone Intervention to LEssen depression/Anxiety and GAIN resilience: SMILE AGAIN project): a protocol for a randomized controlled trial.
Uchida M, Furukawa TA, Yamaguchi T, Imai F, Momino K, Katsuki F, Sakurai N, Miyaji T, Horikoshi M, Iwata H, Zenda S, Iwatani T, Ogawa A, Inoue A, Abe M, Toyama T, Uchitomi Y, Matsuoka H, Noma H, Akechi T. Uchida M, et al. Trials. 2023 May 22;24(1):344. doi: 10.1186/s13063-023-07307-y. Trials. 2023. PMID: 37217965 Free PMC article. - Effects of open-label placebos in clinical trials: a systematic review and meta-analysis.
von Wernsdorff M, Loef M, Tuschen-Caffier B, Schmidt S. von Wernsdorff M, et al. Sci Rep. 2021 Feb 16;11(1):3855. doi: 10.1038/s41598-021-83148-6. Sci Rep. 2021. PMID: 33594150 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous