Exercise-based rehabilitation for heart failure - PubMed (original) (raw)

Review

Exercise-based rehabilitation for heart failure

Rod S Taylor et al. Cochrane Database Syst Rev. 2014.

Update in

Abstract

Background: Previous systematic reviews and meta-analyses consistently show the positive effect of exercise-based rehabilitation for heart failure (HF) on exercise capacity; however, the direction and magnitude of effects on health-related quality of life, mortality and hospital admissions in HF remain less certain. This is an update of a Cochrane systematic review previously published in 2010.

Objectives: To determine the effectiveness of exercise-based rehabilitation on the mortality, hospitalisation admissions, morbidity and health-related quality of life for people with HF. Review inclusion criteria were extended to consider not only HF due to reduced ejection fraction (HFREF or 'systolic HF') but also HF due to preserved ejection fraction (HFPEF or 'diastolic HF').

Search methods: We updated searches from the previous Cochrane review. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue1, 2013) from January 2008 to January 2013. We also searched MEDLINE (Ovid), EMBASE (Ovid), CINAHL (EBSCO) and PsycINFO (Ovid) (January 2008 to January 2013). We handsearched Web of Science, bibliographies of systematic reviews and trial registers (Controlled-trials.com and Clinicaltrials.gov).

Selection criteria: Randomised controlled trials of exercise-based interventions with six months' follow-up or longer compared with a no exercise control that could include usual medical care. The study population comprised adults over 18 years and were broadened to include individuals with HFPEF in addition to HFREF.

Data collection and analysis: Two review authors independently screened all identified references and rejected those that were clearly ineligible. We obtained full-text papers of potentially relevant trials. One review author independently extracted data from the included trials and assessed their risk of bias; a second review author checked data.

Main results: We included 33 trials with 4740 people with HF predominantly with HFREF and New York Heart Association classes II and III. This latest update identified a further 14 trials. The overall risk of bias of included trials was moderate. There was no difference in pooled mortality between exercise-based rehabilitation versus no exercise control in trials with up to one-year follow-up (25 trials, 1871 participants: risk ratio (RR) 0.93; 95% confidence interval (CI) 0.69 to 1.27, fixed-effect analysis). However, there was trend towards a reduction in mortality with exercise in trials with more than one year of follow-up (6 trials, 2845 participants: RR 0.88; 95% CI 0.75 to 1.02, fixed-effect analysis). Compared with control, exercise training reduced the rate of overall (15 trials, 1328 participants: RR 0.75; 95% CI 0.62 to 0.92, fixed-effect analysis) and HF specific hospitalisation (12 trials, 1036 participants: RR 0.61; 95% CI 0.46 to 0.80, fixed-effect analysis). Exercise also resulted in a clinically important improvement superior in the Minnesota Living with Heart Failure questionnaire (13 trials, 1270 participants: mean difference: -5.8 points; 95% CI -9.2 to -2.4, random-effects analysis) - a disease specific health-related quality of life measure. However, levels of statistical heterogeneity across studies in this outcome were substantial. Univariate meta-regression analysis showed that these benefits were independent of the participant's age, gender, degree of left ventricular dysfunction, type of cardiac rehabilitation (exercise only vs. comprehensive rehabilitation), mean dose of exercise intervention, length of follow-up, overall risk of bias and trial publication date. Within these included studies, a small body of evidence supported exercise-based rehabilitation for HFPEF (three trials, undefined participant number) and when exclusively delivered in a home-based setting (5 trials, 521 participants). One study reported an additional mean healthcare cost in the training group compared with control of USD3227/person. Two studies indicated exercise-based rehabilitation to be a potentially cost-effective use of resources in terms of gain in quality-adjusted life years (QALYs) and life-years saved.

Authors' conclusions: This updated Cochrane review supports the conclusions of the previous version of this review that, compared with no exercise control, exercise-based rehabilitation does not increase or decrease the risk of all-cause mortality in the short term (up to 12-months' follow-up) but reduces the risk of hospital admissions and confers important improvements in health-related quality of life. This update provides further evidence that exercise training may reduce mortality in the longer term and that the benefits of exercise training on appear to be consistent across participant characteristics including age, gender and HF severity. Further randomised controlled trials are needed to confirm the small body of evidence seen in this review for the benefit of exercise in HFPEF and when exercise rehabilitation is exclusively delivered in a home-based setting.

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Conflict of interest statement

Rod Taylor and Hayes Dalal are co‐lead investigators on an ongoing National Institute for Health Research (NIHR) Programme Grants for Applied Research funded study ‐ Rehabilitation Enablement in Chronic Heart Failure (REACH‐HF) ‐ to develop and evaluate the costs and outcomes of a home‐based self help heart failure exercise rehabilitation manual (RP‐PG‐1210‐12004).

Figures

Figure 1

Figure 1

Figure 2

Figure 2

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

Figure 3

Figure 3

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

Figure 4

Figure 4

Funnel plot of comparison: 1 All exercise interventions versus usual care, outcome: 1.1 All‐cause mortality up to 12 months' follow‐up.

Figure 5

Figure 5

Funnel plot of comparison: 1 All exercise interventions versus usual care, outcome: 1.6 Health‐related quality of life ‐ Minnesota Living with Heart Failure (MLWHF) questionnaire up to 12 months' follow‐up.

Figure 6

Figure 6

Funnel plot of comparison: 1 All exercise interventions versus usual care, outcome: 1.7 Health‐related quality of life ‐ Minnesota Living with Heart Failure (MLWHF) questionnaire and other scales.

Analysis 1.1

Analysis 1.1

Comparison 1 All exercise interventions versus usual care, Outcome 1 All‐cause mortality up to12 months' follow‐up.

Analysis 1.2

Analysis 1.2

Comparison 1 All exercise interventions versus usual care, Outcome 2 All‐cause mortality more than 12 months' follow‐up.

Analysis 1.3

Analysis 1.3

Comparison 1 All exercise interventions versus usual care, Outcome 3 Hospital admission up to 12 months' follow‐up.

Analysis 1.4

Analysis 1.4

Comparison 1 All exercise interventions versus usual care, Outcome 4 Hospital admission heart failure only.

Analysis 1.5

Analysis 1.5

Comparison 1 All exercise interventions versus usual care, Outcome 5 Hospital admission more than 12 months' follow‐up.

Analysis 1.6

Analysis 1.6

Comparison 1 All exercise interventions versus usual care, Outcome 6 Health‐related quality of life ‐ MLWHF up to 12 months' follow‐up.

Analysis 1.7

Analysis 1.7

Comparison 1 All exercise interventions versus usual care, Outcome 7 Health‐related quality of life ‐ MLWHF and other scales.

Analysis 1.8

Analysis 1.8

Comparison 1 All exercise interventions versus usual care, Outcome 8 Health‐related quality of life ‐ MLWHF 12 months' follow‐up.

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References

References to studies included in this review

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References to ongoing studies

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References to other published versions of this review

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